Аннотация:Background: Migraine, a prevalent type of headache, significantly impacts social and professional functionality due to its high frequency and associated morbidities. This debilitating condition affects various demographics, including university and medical students, and poses a considerable health challenge in Pakistan. Objective: This systematic review aims to establish the prevalence of migraine among different population groups in Pakistan. Methods: An extensive literature search was conducted using databases such as PubMed, Google Scholar, Directory of Open Access Journals (DOAJ), PakMediNet, and ScienceDirect. The search focused on literature published from 2001 to 2023, including cross-referencing article citations. Results: A total of 19 studies were analyzed, highlighting that Karachi city had the highest reported number of migraineurs (3,089 individuals, including 268 medical students). Lahore City followed with 516 cases (452 among general university students). Rawalpindi City reported 201 cases. A nationwide survey indicated 393 migraine incidents. Additionally, Faisalabad, Bahawalpur, and Peshawar reported 175 physicians and medical students, 28 general university students, and 155 medical students with migraines, respectively. Conclusion: The prevalence of migraine is notably high within the Pakistani population, particularly among university and medical students.