A systematic literature review reveals that noninvasive neuromodulation (rTMS, tDCS) changes resting-state fMRI in adults with substance-related and addictive disordersстатья из журнала
Аннотация: Abstract Introduction: Substance-related and addictive disorders (SRADs) are chronic, relapsing psychiatric disorders. Craving is challenging to treat and is a crucial predictor of relapse. Noninvasive neuromodulation approaches are promising to target circuits important for craving at rest, including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). In addition, resting-state functional connectivity (rs-FC) helps investigate how neuromodulation engages neural substrates in a task-free manner. Yet, researchers do not know whether and how neuromodulation methods might change rs-FC in SRAD patients. Objective: We conducted a systematic literature review to investigate whether and how rTMS and tDCS modulate rs-FC across SRADs. Methods: We performed a PRISMA guidelines systematic literature search in the CENTRAL and PubMed databases using search strings for SRADs, rTMS, tDCS, and rs-fMRI. Our inclusion criteria were based on the PICO framework of "participant" (adults with SRADs, and all derivative terms), "intervention "(rTMS or tDCS), "comparator" (sham control), and "outcome" (rs-FC). Results: Our preliminary results identified rTMS and tDCS studies that mainly investigated alcohol, methamphetamine, or tobacco use disorders. Studies predominantly targeted the dorsolateral prefrontal cortex and used seed-based analyses. rTMS and tDCS primarily modulated rs-FC of frontal, fronto-parietal, and fronto-temporal networks, the latter two associated with craving reductions. Other circuits were also modulated (e.g., containing frontal, insular, temporal, parietal, or subcortical areas), with some related to reduced craving. Finalized results will be presented in February. Conclusions: Abundant studies now show that rTMS or tDCS change rs-FC of specific circuits with local and distal regions to the target location in SRADs. The initial seed choices for rs-FC may explain some of the heterogeneous results. Ongoing work links rs-FC changes to craving reductions, which pave the way for potential therapeutic targets and approaches. Rs-FC changes may also help with personalized targeting and treatments. Research Category and Technology and Methods Clinical Research: 18. Functional Brain Imaging Keywords: Substance-related and addictive disorders, Repetitive transcranial magnetic stimulation, Transcranial direct current stimulation, Resting-state fMRI
Год издания: 2023
Авторы: Amy E. Bouchard, Shirley Fecteau, Mark S. George
Издательство: Elsevier BV
Источник: Brain stimulation
Ключевые слова: Transcranial Magnetic Stimulation Studies, Functional Brain Connectivity Studies, Neural and Behavioral Psychology Studies
Открытый доступ: gold
Том: 16
Выпуск: 2
Страницы: 5–6