The differential dendritic cell properties in response to candida albicans and non-albican candida β-glucandissertation
Аннотация: Increased mortality and antifungal drug resistance of non-albicans Candidiasis patients have become an alarming in health problems nowadays, whereas profound knowledge of their pathogenesis mechanisms is still limited. The immune responses of innate and adaptive immunity play a crucial role in protecting from Candida infections. Dendritic cells (DCs) are the most notable because of their roles in bridging an innate immunity and specific adaptive immunity to eliminate fungal invasion. It is little known about DC functions in non-albicans Candida (NACs) infections. Besides, there is less study on evaluating the DC properties upon the interaction between DCs and NACs-derived ß-glucans. Therefore, this work compared DC properties in response to ß-glucans isolated from currently common NACs. As a result, DC maturation and cytokine production altered at various degrees in Candida species-dependent manner. This observation possibly resulted from the structural and morphological differences of ß-glucans of distinct Candida species. Notably, C. krusei ß-glucan could increase the most robust DC activation of enhanced maturation, pro-inflammatory and anti-inflammatory cytokine secretion, whereas ß-glucan of C. tropicalis and C. albicans had similar lower levels of those effects. Moreover, ß-glucan of the former species could influence DCs in both dectin-1-dependent and -independent, distinguished from two latter species. Interestingly, ß-glucan of C. krusei enhanced IL-10 production of DCs, which might expand the high IL-10-producing FoxP3- regulatory T (Treg) cells in vivo C. krusei infection. However, this hypothesis needs further proof. We propose that increased immunomodulation due to C. krusei ß-glucan might prevent the host's protective immune activities and promote immune evasion of C. krusei. In summary, we have shown that altering DC functions of NACs-derived ß-glucans might play a role in NACs infections' pathogenesis. Key words: Glucan, dendritic cells, non-albicans Candida species (NACs)
Год издания: 2020
Авторы: Truc Thi Huong Dinh
Ключевые слова: Antifungal resistance and susceptibility, Probiotics and Fermented Foods, Fungal Infections and Studies
Открытый доступ: hybrid