Anti-Inflammatory, Antimicrobial, Antioxidant and Photoprotective Investigation of Red Propolis Extract as Sunscreen Formulation in Polawax Creamстатья из журнала
Аннотация: Many activities have been described for propolis, including, antiviral, antibacterial, antifungal, anti-inflammatory, immunoregulatory, antioxidant and wound healing properties. Recently, propolis has been highlighted due to its potential application in the pharmaceutical and cosmetic industries, motivating a better understanding of its antioxidant and anti-inflammatory activities. Propolis and its main polyphenolic compounds presented high antioxidant activity, and effectiveness as broad spectrum UVB and UVA photoprotection sunscreens. Through a qualitative phytochemical screening, the ethanolic red propolis extracts (EEPV) (70% at room temperature and 70% at a hot temperature) presented a positive result for flavonoids and terpenoids. It presented an antioxidant activity for reducing 50% of DPPH of 17 and 12 μg/mL for extraction at room temperature and at a hot temperature, respectively. The UPLC-QTOF-MS/MS analysis allowed the annotation of 40 substances for EEPV-Heated and 42 substances for EEPV-Room Temperature. The IC50 results of the ABTS scavenging activity was 4.7 μg/mL for both extractions, at room temperature and at a hot temperature. Additionally, we also evaluated the cytotoxic profile of propolis extracts against macrophage (RAW 264.7 cells) and keratinocytes (HaCaT cells), which showed non-cytotoxic doses in cell viability assays even after a long period of exposure. In addition, propolis extracts showed antibacterial activity for Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), demonstrating potential biological activity for the creation of formulations aimed at disease control and prevention.
Год издания: 2023
Авторы: Thalita Marcolan Valverde, Bruna Nayane Goncalves de Souza Soares, Andréa Mendes do Nascimento, Ângela Leão Andrade, Lucas Resende Dutra Sousa, Paula Melo de Abreu Vieira, Vagner Rodrigues Santos, Janaína Brandão Seibert, Tatiane Cristine Silva de Almeida, Caio Fabrini Rodrigues, Samantha Roberta Machado de Oliveira, Flaviano S. Martins, Jeronimo Geraldo Ferreira Júnior, Viviane Martins Rebello dos Santos
Издательство: Multidisciplinary Digital Publishing Institute
Источник: International Journal of Molecular Sciences
Ключевые слова: Bee Products Chemical Analysis, Phytochemistry Medicinal Plant Applications, Essential Oils and Antimicrobial Activity
Другие ссылки: International Journal of Molecular Sciences (PDF)
International Journal of Molecular Sciences (HTML)
PubMed Central (HTML)
PubMed (HTML)
International Journal of Molecular Sciences (HTML)
PubMed Central (HTML)
PubMed (HTML)
Открытый доступ: gold
Том: 24
Выпуск: 6
Страницы: 5112–5112