Esmethadone-HCl (REL-1017): a promising rapid antidepressantreview
Аннотация: Abstract This review article presents select recent studies that form the basis for the development of esmethadone into a potential new drug. Esmethadone is a promising member of the pharmacological class of uncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonists that have shown efficacy for major depressive disorder (MDD) and other diseases and disorders, such as Alzheimer’s dementia and pseudobulbar affect. The other drugs in the novel class of NMDAR antagonists with therapeutic uses that are discussed for comparative purposes in this review are esketamine, ketamine, dextromethorphan, and memantine. We present in silico, in vitro, in vivo, and clinical data for esmethadone and other uncompetitive NMDAR antagonists that may advance our understanding of the role of these receptors in neural plasticity in health and disease. The efficacy of NMDAR antagonists as rapid antidepressants may advance our understanding of the neurobiology of MDD and other neuropsychiatric diseases and disorders.
Год издания: 2023
Авторы: Maurizio Fava, Stephen M. Stahl, Sara De Martin, Andrea Mattarei, Ezio Bettini, Stefano Comai, Andrea Alimonti, Francesco Bifari, Luca Pani, Franco Folli, Clotilde Guidetti, Alberto Furlan, Jacopo Sgrignani, Patrizia Locatelli, Andrea Cavalli, Cedric O’Gorman, Sergio Traversa, Charles E. Inturrisi, M. Pappagallo, Paolo L. Manfredi
Издательство: Springer Science+Business Media
Источник: European Archives of Psychiatry and Clinical Neuroscience
Ключевые слова: Treatment of Major Depression, Neuroscience and Neuropharmacology Research, Neurotransmitter Receptor Influence on Behavior
Другие ссылки: European Archives of Psychiatry and Clinical Neuroscience (PDF)
European Archives of Psychiatry and Clinical Neuroscience (HTML)
Repository for Publications and Research Data (ETH Zurich) (PDF)
Repository for Publications and Research Data (ETH Zurich) (HTML)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (PDF)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (HTML)
PubMed Central (HTML)
PubMed (HTML)
European Archives of Psychiatry and Clinical Neuroscience (HTML)
Repository for Publications and Research Data (ETH Zurich) (PDF)
Repository for Publications and Research Data (ETH Zurich) (HTML)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (PDF)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (HTML)
PubMed Central (HTML)
PubMed (HTML)
Открытый доступ: hybrid
Том: 273
Выпуск: 7
Страницы: 1463–1476