Аннотация:Abstract Hematopoietic stem cells (HSCs) hold the unique capacity to restore the entire blood system throughout life. To preserve life-long stem cell functionality, metabolic, epigenetic and transcriptional drivers form complex regulatory networks to tightly regulate HSCs. This interplay can be controlled by single metabolites, especially vitamins, instructing those epigenetic and transcriptional attributes. A non-classical retinoic acid (RA) signaling axis has been shown to be indispensable for protection of stem cell features in HSCs.
