Abstracts From the 46th Annual Conference on Cardiovascular Disease Epidemiology and Preventionстатья из журнала
Аннотация: High white matter grade (WMG) on brain cranial magnetic resonance imaging (MRI) is associated with elevated systolic blood pressure (SBP) and other measures of clinical and subclinical cardiovascular disease (CVD), and is a risk factor for clinical stroke, dementia, and declining physical functioning.High WMG is likely due to small vessel disease, which may contribute to loss of brain tissue with ventricular enlargement and high ventricular grade (VG) on MRI.In the Cardiovascular Health Study (CHS), we evaluated the relationship of WMG and VG, measured on a scale from 0 (no WM hyperintensity) to 9 (most severe) in 1992-94, to total and cause-specific mortality through June 30, 2002 among 3,240 women and men, mean age 75.We tested the hypothesis that higher WMG and VG were related to risk of total and CVD mortality after adjustment for other key risk factors.All-cause, CVD, and non-CVD death rates increased with increasing WMG and VG grades.For example, for women aged 65-74, the all-cause death rate was 16.6 per 1,000 person-years for WMG Ͻ 2 compared to 54.4 for WMG Ͼ6.The association remained after adjustment for CVD risk factors.The higher mortality for increasing WMG and VG persisted over the 12-year follow up.Risk associated with WMG or VG did not differ by sex, race or age (p interactions all Ͼ0.05).Participants who were below the median for both WMG and VG had a hazards ratio of 0.61 (0.43-0.87) of death compared to participants at or above the median on both measures.At age 75, the average survival of participants with WMG and VG below the median and without subclinical CVD was 18.7 years, to approximately age 93, compared to 11.5 years for those with WMG and VG at or above the median and with subclinical disease.These variables may have the strongest associations of any variable with longevity among older individuals.High WMG and VG on MRI are strongly associated with mortality in older persons, possibly reflecting the effects of small vessel disease in the brain.
Год издания: 2006
Издательство: Lippincott Williams & Wilkins
Источник: Circulation
Ключевые слова: Cardiovascular Health and Risk Factors
Открытый доступ: bronze
Том: 113
Выпуск: 8