Аннотация:Purpose:The common marmoset (marmoset) is small primates, which their body weights are about the same as rats.Functional Observational Battery (FOB) is a test to evaluate the effect of a compound on the central nervous systems (CNS) in drug development.In this study, we investigated if the marmoset is useful to possess high-sensitivity primate-specific FOB.Methods:Saline, Cocaine (Coc 2 or 1 mg/kg) or Chlorpromazine (Cpz 3 or 1 mg/kg) was intravenously administered to four male marmosets.FOB (general condition, motor function, etc.) was performed 5 minutes to 6 hours after the administration.Results:Rapid and Slight movements of the head which is sepcific for the non-human primate, continual movement, hyperirritability and hyperthermia were observed at 5 min after administration in Coc 2 mg/kg group.Although continual movement, hyperirritability and hyperthermia were also observed in Coc 1 mg/kg group, expression of other symptoms were decreased.Eye-closing, hypoactivity, slowed motion and ataxia were observed at 5 min after administration of Cpz 3 mg/kg.Eye-closing, hypoactivity were also observed in Cpz 1 mg/kg group, but expression of other symptoms were decreased.Discussion:Dose dependent effects of Coc and Cpz on the CNS were able to be detected in the marmoset FOB.Since the primate-specific symptom such as rapid and slight of the head movement was observed in the Coc treatment, FOB in the marmosets may be more useful than that in rats.
