Аннотация:Background and Aims: NOD-like receptor thermal-protein domain related protein (NLRP3) has been considered as important response to virus and bacteria infection.This study aims to investigate and compare the effect of NLRP3 inflammasome between pneumonia in early phase caused by influenza A virus H1N1(H1N1) and methicillin-resistant staphylococcus aureus(MRSA).Methods: Pneumonia caused by intranasal inoculation with IAV H1N1 and MRSA respectively in mice was established.After infected for