Workshopстатья из журнала
Аннотация: Noroviruses (NoVs) are the leading cause of acute epidemic gastroenteritis in worldwide.Because of the extensive damages in health and economics, development of effective vaccines is strongly desired.Virus-like particles (VLPs) which are self-assembled of recombinantly expressed norovirus VP1 protein are made as first generation of vaccine candidate against norovirus.Since noroviruses are known to infect through mucosal surface, induction of IgA Abs by vaccination is thought to be beneficial to provide more effective immunity.In this study, we evaluated the effectiveness of norovirus GI.1-and GII.4-VLP vaccines for human immunity by utilizing a humanized mouse model.This mouse model successfully demonstrates human IgG and IgA class of protective Ab responses after the NoV-VLP vaccination.Notably, although equivalent numbers of IgG and IgA memory B cells specific for each VLP are present in donor PBMCs, IgA Ab responses are markedly enhanced compared with IgG after the vaccination with VLP but not with disrupted VLP which lacks selfassembled VP1 structure, indicating that the highly organized structure of VLP is crucial for IgA enhancement.Thus, our results demonstrate that the highly organized structure of norovirus VLP is an important factor to enhance protective IgA Ab production against noroviruses. WS1-2組換え BCG を用いた，難病に対する多価ワクチンの開発 ○松本 壮吉(新潟大・院・医・細菌) Development of recombinant BCG vaccine against intractable diseases
Год издания: 2021
Авторы: Soichiro Kimura, ○小野寺 大志, 香奈, 戸高 玲子, 長谷川 秀樹, Kelsoe, 片山 和彦, 高橋 宜聖, 国立感染症研究所 免疫部, Taishi Onodera, Kana Hashi, Reiko Todaka, Manabu Ato, Hideki Hasegawa, Kelsoe Garnet, Kazuhiko Katayama, Yoshimasa Takahashi, ○sohkichi Matsumoto, 多価ワクチンとなることが期待される, ・ 細菌学研究, ○金城 感染免疫研究の知見に基づくワクチン開発, Yuki Kinjo, ○kaihei Oki, Toshitaka Odamaki, Noriko Katsumata, Makoto Yoshimoto, Kazuya Ohno, Eri Mitsuyama, Keisuke Yoshida, Takashi Shimizu, Kanetada Shimizu
Издательство: Japanese Society for Bacteriology
Источник: Nippon Saikingaku Zasshi
Открытый доступ: gold
Том: 76
Выпуск: 1
Страницы: 43–62