Аннотация:In 1954, Ed Lewis described transvection, an epigenetic phenomenon wherein the expression of a gene is sensitive to the proximity of a homologous chromosome.Transvection can occur via an enhancer on one chromosome activating a promoter on a paired homolog.Although several cases of such enhancer action in trans are known, it remains unclear whether this capacity is restricted to a subset of enhancers.Blick et al. test a collection of enhancers and find evidence for transvection in all cases, suggesting that this property is common.
