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COMPARISON OF ANTIBACTERIAL EFFICACY OFPHOTODYNAMIC THERAPYAND DOXYCYCLINE ONAGGREGATIBACTERACTINOMYCETEMCOMITANS Ernie Maduratna SetiawatieVina Puji LestariSuryani Dyah2018 год

COMPARISON OF ANTI BACTERIAL EFFICACY OF PHOTODYNAMIC THERAPY AND DOXYCYCLINE ON AGGREGATIBACTER ACTINOMYCETEMCOMITANS
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Аннотация: Background: Aggregatibacter actinomycetemcomitans (A.actinomycetemcomitans) is an anaerobic bacterium has been frequently associated with aggressive periodontitis.Photodynamic therapy (PDT) is a medical treatment to prevent infection progression that utilizes light to activate a photosensitizing agent.Doxycycline is an antibacterial having photosensitivity.This study aimed to evaluate potential doxycycline as an antibacterial and photosensitizer combine PDT against A.actinomycetemcomitans bacteria.Material and methods: Samples were distributed to 4 groups as follow: (1) Groups A treated with a diode laser, (2) Group B treated with doxycycline 0,1% and laser, (3) Group C treated only with Doxycycline 0.1%, and (4) Group D no exposure doxycycline/laser.Data were analyzed by one-way ANOVA and Tukey's HSD test at 5% significance level.Results: In this study, doxycycline 0.1% has the effect of reducing the bacterial viability of (59.60±3.26%).Whereas laser exposure 120 s combined with doxycycline produce the effect of bacterial viability reduction (88.50±2.83%) is not significantly different from the effect of laser 120 s exposure (88.79±2.60%).In clinical treatment, the application of laser exposure is generally at the duration of the exposure time of 30 s.The results of this study indicate that the duration of laser exposure 30 s shows a reduction in bacterial viability (44.91±1.69%)equal to the laser and with a combination of doxycycline and laser exposure (70.70±2.43%).So at low doses of laser exposure, doxycycline 0.1% combined with the laser results in the greatest reduction in bacterial viability, significantly different from laser exposure alone.Conclusion: at low doses of laser exposure (30s with energy 3.68 J/cm 2 ), doxycycline 0.1% combined with the laser results in the greatest reduction in bacterial viability, significantly different with laser exposure alone.
Год издания: 2018
Авторы: Ernie Maduratna Setiawatie, Vina Puji Lestari, Suryani Dyah
Издательство: African Journals OnLine
Источник: African Journal of Infectious Diseases
Ключевые слова: Antimicrobial Peptides and Activities, Biochemical and Structural Characterization, Advanced Drug Delivery Systems
Другие ссылки: African Journal of Infectious Diseases (PDF)
African Journal of Infectious Diseases (HTML)
Universitas Airlangga Repository (Universitas Airlangga) (HTML)
Universitas Airlangga Repository (Universitas Airlangga) (HTML)
Universitas Airlangga Repository (Universitas Airlangga) (HTML)
Universitas Airlangga Repository (Universitas Airlangga) (HTML)
Universitas Airlangga Repository (Universitas Airlangga) (HTML)
Universitas Airlangga Repository (Universitas Airlangga) (HTML)