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Development andvalidation of thesymptom burdenquestionnaire forlong covid (SBQ-LC):Rasch analysis Sarah HughesShamil HaroonAnuradhaa Subramanian2022 год

Development and validation of the symptom burden questionnaire for long covid (SBQ-LC): Rasch analysis
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Аннотация: To describe the development and validation of a novel patient reported outcome measure for symptom burden from long covid, the symptom burden questionnaire for long covid (SBQ-LC).Multiphase, prospective mixed methods study.Remote data collection and social media channels in the United Kingdom, 14 April to 1 August 2021.13 adults (aged ≥18 years) with self-reported long covid and 10 clinicians evaluated content validity. 274 adults with long covid field tested the draft questionnaire.Published systematic reviews informed development of SBQ-LC's conceptual framework and initial item pool. Thematic analysis of transcripts from cognitive debriefing interviews and online clinician surveys established content validity. Consensus discussions with the patient and public involvement group of the Therapies for Long COVID in non-hospitalised individuals: From symptoms, patient reported outcomes and immunology to targeted therapies (TLC Study) confirmed face validity. Rasch analysis of field test data guided item and scale refinement and provided initial evidence of the SBQ-LC's measurement properties.SBQ-LC (version 1.0) is a modular instrument measuring patient reported outcomes and is composed of 17 independent scales with promising psychometric properties. Respondents rate their symptom burden during the past seven days using a dichotomous response or 4 point rating scale. Each scale provides coverage of a different symptom domain and returns a summed raw score that can be transformed to a linear (0-100) score. Higher scores represent higher symptom burden. After rating scale refinement and item reduction, all scales satisfied the Rasch model requirements for unidimensionality (principal component analysis of residuals: first residual contrast values <2.00 eigenvalue units) and item fit (outfit mean square values within 0.5 -1.5 logits). Rating scale categories were ordered with acceptable category fit statistics (outfit mean square values <2.0 logits). 14 item pairs had evidence of local dependency (residual correlation values >0.4). Across the 17 scales, person reliability ranged from 0.34 to 0.87, person separation ranged from 0.71 to 2.56, item separation ranged from 1.34 to 13.86, and internal consistency reliability (Cronbach's alpha) ranged from 0.56 to 0.91.SBQ-LC (version 1.0) is a comprehensive patient reported outcome instrument developed using modern psychometric methods. It measures symptoms of long covid important to people with lived experience of the condition and may be used to evaluate the impact of interventions and inform best practice in clinical management.
Год издания: 2022
Авторы: Sarah Hughes, Shamil Haroon, Anuradhaa Subramanian, Christel McMullan, Olalekan Lee Aiyegbusi, Grace Turner, Louise Jackson, Elin Haf Davies, Chris Frost, Gary McNamara, Gary Price, Karen Matthews, Jennifer Camaradou, Jane Ormerod, Anita Walker, Melanie Calvert
Источник: BMJ
Ключевые слова: Long-Term Effects of COVID-19, COVID-19 and Mental Health, Intensive Care Unit Cognitive Disorders
Другие ссылки: BMJ (PDF)
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University of Birmingham Research Portal (University of Birmingham) (HTML)
University of Birmingham Research Portal (University of Birmingham) (PDF)
University of Birmingham Research Portal (University of Birmingham) (HTML)
PubMed Central (HTML)
www.medrxiv.org (PDF)
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