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Hyaluronic acid inthe treatment of dryeye disease Leif HynnekleivMorten Schjerven MagnøRagnheidur R. Vernhardsdottir2022 год

Hyaluronic acid in the treatment of dry eye disease
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Abstract Dry eye disease (DED) is a highly prevalent and debilitating condition affecting several hundred million people worldwide. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan commonly used in the treatment of DED. This review aims to critically evaluate the literature on the safety and efficacy of artificial tears containing HA used in DED treatment. Literature searches were conducted in PubMed, including MEDLINE, and in Embase via Ovid with the search term: “(hyaluronic acid OR hyaluronan OR hyaluronate) AND (dry eye OR sicca)”. A total of 53 clinical trials are included in this review, including eight placebo‐controlled trials. Hyaluronic acid concentrations ranged from 0.1% to 0.4%. Studies lasted up to 3 months. A broad spectrum of DED types and severities was represented in the reviewed literature. No major complications or adverse events were reported. Artificial tears containing 0.1% to 0.4% HA were effective at improving both signs and symptoms of DED. Two major gaps in the literature have been identified: 1. no study investigated the ideal drop frequency for HA‐containing eyedrops, and 2. insufficient evidence was presented to recommend any specific HA formulation over another. Future investigations assessing the optimal drop frequency for different concentrations and molecular weights of HA, different drop formulations, including tonicity, and accounting for DED severity and aetiology are essential for an evidence‐based, individualized approach to DED treatment.
Год издания: 2022
Авторы: Leif Hynnekleiv, Morten Schjerven Magnø, Ragnheidur R. Vernhardsdottir, Emily Moschowits, Kim Alexander Tønseth, Darlene A. Dartt, Jelle Vehof, Tor Paaske Utheim
Издательство: Wiley
Источник: Acta Ophthalmologica
Ключевые слова: Ocular Surface and Contact Lens, Glaucoma and retinal disorders, Advanced Drug Delivery Systems
Другие ссылки: Acta Ophthalmologica (PDF)
Acta Ophthalmologica (HTML)
University of Groningen research database (University of Groningen / Centre for Information Technology) (HTML)
Data Archiving and Networked Services (DANS) (PDF)
Data Archiving and Networked Services (DANS) (HTML)
Duo Research Archive (University of Oslo) (PDF)
Duo Research Archive (University of Oslo) (HTML)
PubMed Central (HTML)
PubMed (HTML)