IC‐P‐084: Positive effects of a 6‐month stage‐specific cognitive intervention program on brain metabolism in subjects with amnestic mild cognitive impairment (aMCI) and mild Alzheimer's disease (AD)статья из журнала
Аннотация: Cognitive intervention has recently been found to be beneficial in patients with MCI and mild AD, but the effect of cognitive training on brain metabolism is unknown. We used F-18 fluoro-2-deoxy-glucose (FDG) positron emission tomography (PET) to measure the progression of declining cerebral glucose metabolism in aMCI/AD patients during six months, and to test effects of a newly-developed stage-specific cognitive intervention program on these reductions. In this randomised and controlled trial, 21 subjects with aMCI and 15 patients with mild AD (20 m, mean age 74 years) were assigned either to a cognitive intervention group (CIG), receiving weekly sessions of cognitive intervention, which was tailored to the stage of cognitive impairment, or to an active control group (CG), which met monthly and received only pencil and paper exercises for self-study. Groups were matched for age-, gender- and MMSE. All subjects underwent resting-state FDG PET scanning (Philips Allegro scanner) and also extensive neuropsychological testing at baseline, and again at six-month follow-up. PET images of FDG uptake were analyzed using SPM. Changes in regional glucose metabolism from baseline were determined in both groups (p < 0.001) and a “difference of differences” analysis between these in-group changes was performed (p < 0.005). At six-month follow-up, the CG subjects showed widespread bilateral declines in glucose metabolism in parietal, temporal, frontal, and posterior cingulate cortices. In contrast, the CIG subjects showed only discrete declines in glucose metabolism, mainly in bilateral prefrontal cortex and left inferior temporal cortex. The “difference of differences” analysis revealed in the CIG a pattern of attenuated reduction in glucose metabolism, with significant clusters in the right parietal, temporal-, cingulate- and frontal cortices, and to a lesser degree in the left superior parietal- and frontal cortices. Pilot data in our group of aMCI and mild AD subjects show that participation for six-months in a stage-specific cognitive intervention program imparted cognitive benefits, which were linked the first time to a delayed progression of reduced glucose metabolism, notably in brain regions typically affected by AD. Based on these results, we are initiating an investigation in a larger population and over a longer observation period.
Год издания: 2009
Авторы: Stefan Foerster, Verena Buschert, Hans Georg Buchholz, Stefan Teipel, Christian Zach, Harald Hampel, Peter Bartenstein, Katharina Büerger
Издательство: Wiley
Источник: Alzheimer s & Dementia
Ключевые слова: Dementia and Cognitive Impairment Research, Cerebrovascular and Carotid Artery Diseases
Открытый доступ: closed
Том: 5
Выпуск: 4S_Part_2