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Lysosomal Physiology Haoxing XuDejian Ren2015 год

Lysosomal Physiology
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Lysosomes are acidic compartments filled with more than 60 different types of hydrolases. They mediate the degradation of extracellular particles from endocytosis and of intracellular components from autophagy. The digested products are transported out of the lysosome via specific catabolite exporters or via vesicular membrane trafficking. Lysosomes also contain more than 50 membrane proteins and are equipped with the machinery to sense nutrient availability, which determines the distribution, number, size, and activity of lysosomes to control the specificity of cargo flux and timing (the initiation and termination) of degradation. Defects in degradation, export, or trafficking result in lysosomal dysfunction and lysosomal storage diseases (LSDs). Lysosomal channels and transporters mediate ion flux across perimeter membranes to regulate lysosomal ion homeostasis, membrane potential, catabolite export, membrane trafficking, and nutrient sensing. Dysregulation of lysosomal channels underlies the pathogenesis of many LSDs and possibly that of metabolic and common neurodegenerative diseases.
Год издания: 2015
Авторы: Haoxing Xu, Dejian Ren
Издательство: Annual Reviews
Источник: Annual Review of Physiology
Ключевые слова: Calcium signaling and nucleotide metabolism, Cellular transport and secretion, Lysosomal Storage Disorders Research
Другие ссылки: Annual Review of Physiology (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)