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Comparative ProteinStructure ModelingUsing MODELLER Benjamin WebbAndrej Šali2016 год

Comparative Protein Structure Modeling Using MODELLER
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Аннотация: Abstract Comparative protein structure modeling predicts the three‐dimensional structure of a given protein sequence (target) based primarily on its alignment to one or more proteins of known structure (templates). The prediction process consists of fold assignment, target‐template alignment, model building, and model evaluation. This unit describes how to calculate comparative models using the program MODELLER and how to use the ModBase database of such models, and discusses all four steps of comparative modeling, frequently observed errors, and some applications. Modeling lactate dehydrogenase from Trichomonas vaginalis (TvLDH) is described as an example. The download and installation of the MODELLER software is also described. © 2016 by John Wiley & Sons, Inc.
Год издания: 2016
Авторы: Benjamin Webb, Andrej Šali
Издательство: Wiley
Источник: Current Protocols in Bioinformatics
Ключевые слова: Enzyme Structure and Function, Protein Structure and Dynamics, Genomics and Phylogenetic Studies
Другие ссылки: Current Protocols in Bioinformatics (HTML)
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Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
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