Аннотация:At the same time last year we were very much hoping that the extraordinary research and clinical efforts deployed in response to the pandemic outbreak would mean that we would have stepped out of the rollercoaster wagon this year.[1] But here we are in early 2022: the roller coaster elevating again ready for the next vertical plunge. On this ride, however, we came over unprecedented challenges and worldwide scientific collaboration towards vaccine development was accomplished at a speed and efficiency never imaginable so far. As it became evident thrombosis is playing an intrinsic part of COVID-19, our scientific community naturally fully engaged in this race against the disease. In this New Year Editorial, we reflect back on this rollercoaster year, which 2021 has presented to us all, and project ourselves into the New Year 2022.