Аннотация:Contents malignancies, usually seen in peri-or post-menopausal women.Criteria for diagnosis of fibrosarcoma include mitotic count, the most important feature for distinguishing between benign and malignant lesions.Only few cases have been reported due to its low incidence and poor prognosis.These tumors are easily misdiagnosed so sometimes diagnosis is primarily based on histopathological and immunohistochemistry (IHC) report as in our case report.We report a rare case of ovarian fibrosarcoma.Methods: A 40 year, P5L5, woman visited to gynecological oncology department of IGIMS, Patna, with complain of abdominal distention for 6 months.Her menstrual history was regular with average flow.On abdominal examination-a lump of 32 week size with mobility found.On vaginal examinationcervix was healthy, uterine size could not be assessed due to such huge mass.Her tumor markers showed raised cancer antigen 125 level with value of 152.7.Other tumor markers were within normal limit.Computed tomography abdomen showed 22×19×16 cm mass in left adenexa with multiple septae and few cystic areas.Results: Primary debulking surgery done.Final pathological diagnosis was fibrosarcoma of left ovary.IHC showed ki-67-35%.Conclusion: Primary ovarian fibrosarcomas is a rare neoplasm of ovary but it must be considered as differential diagnosis of unilateral huge solid ovarian mass in all age group.ki-67 along with mitosis, greater than 4 mitotic areas/HPF, has recently become an important indicator for diagnosis of ovarian fibrosarcoma.Preoperative diagnosis is often difficult.Gynaeoncologist has to wait for histopathological and IHC report for final diagnosis.
