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COVID-19 Infection inChildren, Infants andPregnant Subjects: AnOverview of RecentInsights andTherapies Giuseppina MalcangiAlessio Danilo InchingoloAngelo Michele Inchingolo2021 год

COVID-19 Infection in Children, Infants and Pregnant Subjects: An Overview of Recent Insights and Therapies
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Background: The SARS-CoV-2 pandemic has involved a severe increase of cases worldwide in a wide range of populations. The aim of the present investigation was to evaluate recent insights about COVID-19 infection in children, infants and pregnant subjects. Methods: a literature overview was performed including clinical trials, in vitro studies, reviews and published guidelines regarding the present paper topic. A descriptive synthesis was performed to evaluate recent insights and the effectiveness of therapies for SARS-CoV-2 infection in children, infants and pregnant subjects. Results: Insufficient data are available regarding the relationship between COVID-19 and the clinical risk of spontaneous abortion and premature foetus death. A decrease in the incidence of COVID-19 could be correlated to a minor expression of ACE2 in childrens’ lungs. At present, a modulation of the dose-effect posology for children and infants is necessary. Conclusions: Pregnant vertical transmission has been hypothesised for SARS-CoV-2 infection. Vaccines are necessary to achieve mass immunity for children and also pregnant subjects.
Год издания: 2021
Авторы: Giuseppina Malcangi, Alessio Danilo Inchingolo, Angelo Michele Inchingolo, Luigì Santacroce, Grazia Marinelli, Antonio Mancini, Luigi Vimercati, Maria Elena Maggiore, Maria Teresa D’Oria, Denisa Hazballa, Ioana Roxana Bordea, Edit Xhajanka, Antônio Scarano, Marco Farronato, Gianluca Martino Tartaglia, Delia Giovanniello, Ludovica Nucci, R Serpico, Gilberto Sammartino, Loredana Capozzi, Antonio Parisi, Marina Di Domenico, Felice Lorusso, Maria Contaldo, Francesco Inchingolo, Gianna Dipalma
Издательство: Multidisciplinary Digital Publishing Institute
Источник: Microorganisms
Ключевые слова: COVID-19 Impact on Reproduction, Neonatal Respiratory Health Research, COVID-19 Clinical Research Studies
Другие ссылки: Microorganisms (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (PDF)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (HTML)
PubMed Central (HTML)
PubMed (HTML)