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Prognostic value ofneutrophil‐to‐lymphocyte ratio in COVID‐19patients: Asystematic review andmeta‐analysis Juan R. Ulloque‐BadaraccoW. Ivan Salas‐TelloAli Al‐kassab‐Córdova2021 год

Prognostic value of neutrophil‐to‐lymphocyte ratio in COVID‐19 patients: A systematic review and meta‐analysis

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Neutrophil-to-lymphocyte ratio (NLR) is an accessible and widely used biomarker. NLR may be used as an early marker of poor prognosis in patients with COVID-19.To evaluate the prognostic value of the NLR in patients diagnosed with COVID-19.We conducted a systematic review and meta-analysis. Observational studies that reported the association between baseline NLR values (ie, at hospital admission) and severity or all-cause mortality in COVID-19 patients were included. The quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS). Random effects models and inverse variance method were used for meta-analyses. The effects were expressed as odds ratios (ORs) and their 95% confidence intervals (CIs). Small study effects were assessed with the Egger's test.We analysed 61 studies (n = 15 522 patients), 58 cohorts, and 3 case-control studies. An increase of one unit of NLR was associated with higher odds of severity (OR 6.22; 95%CI 4.93 to 7.84; P < .001) and higher odds of all-cause mortality (OR 12.6; 95%CI 6.88 to 23.06; P < .001). In our sensitivity analysis, we found that 41 studies with low risk of bias and moderate heterogeneity (I2 = 53% and 58%) maintained strong association between NLR values and both outcomes (severity: OR 5.36; 95% CI 4.45 to 6.45; P < .001; mortality: OR 10.42 95% CI 7.73 to 14.06; P = .005).Higher values of NLR were associated with severity and all-cause mortality in hospitalised COVID-19 patients.
Год издания: 2021
Авторы: Juan R. Ulloque‐Badaracco, W. Ivan Salas‐Tello, Ali Al‐kassab‐Córdova, Esteban A. Alarcón‐Braga, Vicente A. Benítes-Zapata, Jorge L. Maguiña, Adrían V. Hernández
Издательство: Wiley
Источник: International Journal of Clinical Practice
Ключевые слова: COVID-19 Clinical Research Studies, Long-Term Effects of COVID-19, COVID-19 Impact on Reproduction
Другие ссылки: International Journal of Clinical Practice (HTML)
Zenodo (CERN European Organization for Nuclear Research) (PDF)
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Repositorio Académico UPC (Universidad Peruana de Ciencias Aplicadas) (PDF)
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PubMed Central (HTML)
Repositorio Académico UPC (Universidad Peruana de Ciencias Aplicadas) (PDF)
Repositorio Académico UPC (Universidad Peruana de Ciencias Aplicadas) (HTML)
Authorea (Authorea) (HTML)
PubMed (HTML)