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Emodin: A Review ofits Pharmacology,Toxicity andPharmacokinetics Xiaoxv DongJing FuXingbin Yin2016 год

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics
review

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Аннотация: Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum. Emodin has been used as a traditional Chinese medicine for over 2000 years and is still present in various herbal preparations. Emerging evidence indicates that emodin possesses a wide spectrum of pharmacological properties, including anticancer, hepatoprotective, antiinflammatory, antioxidant and antimicrobial activities. However, emodin could also lead to hepatotoxicity, kidney toxicity and reproductive toxicity, particularly in high doses and with long-term use. Pharmacokinetic studies have demonstrated that emodin has poor oral bioavailability in rats because of its extensive glucuronidation. This review aims to comprehensively summarize the pharmacology, toxicity and pharmacokinetics of emodin reported to date with an emphasis on its biological properties and mechanisms of action. Copyright © 2016 John Wiley & Sons, Ltd.
Год издания: 2016
Авторы: Xiaoxv Dong, Jing Fu, Xingbin Yin, Sali Cao, Xuechun Li, Longfei Lin, Jian Ni
Издательство: Wiley
Источник: Phytotherapy Research
Ключевые слова: Phytochemistry and biological activity of medicinal plants, Chromatography in Natural Products, Biological and pharmacological studies of plants
Другие ссылки: Phytotherapy Research (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)