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Role of P2X7Receptors in ImmuneResponses DuringNeurodegeneration Ágatha Oliveira‐GiacomelliLyvia Lintzmaier PetizRoberta Andrejew2021 год

Role of P2X7 Receptors in Immune Responses During Neurodegeneration
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the extensive release of ATP induces sustained P2X7 receptor activation, culminating in induction of proinflammatory pathways with inflammasome assembly and cytokine release. These inflammatory conditions, whether occurring peripherally or in the central nervous system (CNS), increase blood-brain-barrier (BBB) permeability. Besides its well-known involvement in neurodegeneration and neuroinflammation, the P2X7 receptor may induce BBB disruption and chemotaxis of peripheral immune cells to the CNS, resulting in brain parenchyma infiltration. For instance, despite common effects on cytokine release, P2X7 receptor signaling is also associated with metalloproteinase secretion and activation, as well as migration and differentiation of T lymphocytes, monocytes and dendritic cells. Here we highlight that peripheral immune cells mediate the pathogenesis of Multiple Sclerosis and Parkinson’s and Alzheimer’s disease, mainly through T lymphocyte, neutrophil and monocyte infiltration. We propose that P2X7 receptor activation contributes to neurodegenerative disease progression beyond its known effects on the CNS. This review discusses how P2X7 receptor activation mediates responses of peripheral immune cells within the inflamed CNS, as occurring in the aforementioned diseases.
Год издания: 2021
Авторы: Ágatha Oliveira‐Giacomelli, Lyvia Lintzmaier Petiz, Roberta Andrejew, Natalia Turrini, Jean Bezerra Silva, Ulrich Sack, Henning Ulrich
Издательство: Frontiers Media
Источник: Frontiers in Cellular Neuroscience
Ключевые слова: Adenosine and Purinergic Signaling, Neuroinflammation and Neurodegeneration Mechanisms, Neurological Complications and Syndromes
Другие ссылки: Frontiers in Cellular Neuroscience (PDF)
Frontiers in Cellular Neuroscience (HTML)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (PDF)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (HTML)
Qucosa (Saxon State and University Library Dresden) (PDF)
Qucosa (Saxon State and University Library Dresden) (HTML)
PubMed Central (HTML)
PubMed (HTML)