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Peptide-BasedNanoparticles forTherapeutic NucleicAcid Delivery Prisca BoisguérinKaridia KonateEmilie Josse2021 год

Peptide-Based Nanoparticles for Therapeutic Nucleic Acid Delivery
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Gene therapy offers the possibility to skip, repair, or silence faulty genes or to stimulate the immune system to fight against disease by delivering therapeutic nucleic acids (NAs) to a patient. Compared to other drugs or protein treatments, NA-based therapies have the advantage of being a more universal approach to designing therapies because of the versatility of NA design. NAs (siRNA, pDNA, or mRNA) have great potential for therapeutic applications for an immense number of indications. However, the delivery of these exogenous NAs is still challenging and requires a specific delivery system. In this context, beside other non-viral vectors, cell-penetrating peptides (CPPs) gain more and more interest as delivery systems by forming a variety of nanocomplexes depending on the formulation conditions and the properties of the used CPPs/NAs. In this review, we attempt to cover the most important biophysical and biological aspects of non-viral peptide-based nanoparticles (PBNs) for therapeutic nucleic acid formulations as a delivery system. The most relevant peptides or peptide families forming PBNs in the presence of NAs described since 2015 will be presented. All these PBNs able to deliver NAs in vitro and in vivo have common features, which are characterized by defined formulation conditions in order to obtain PBNs from 60 nm to 150 nm with a homogeneous dispersity (PdI lower than 0.3) and a positive charge between +10 mV and +40 mV.
Год издания: 2021
Авторы: Prisca Boisguérin, Karidia Konate, Emilie Josse, Éric Vivès, Sébastien Deshayes
Издательство: Multidisciplinary Digital Publishing Institute
Источник: Biomedicines
Ключевые слова: RNA Interference and Gene Delivery, Advanced biosensing and bioanalysis techniques, Virus-based gene therapy research
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