Аннотация:The purpose of the presented work was the establishment of a character of modifying influence of ionizing radiation on damages of neurons of internal nuclear and ganglionic layers of a retina caused by light. The investigation revealed that changes of neurons of the internal nuclear and ganglionic layers after X-ray, light (200 lk, the 1 st , 2 nd , 7 th , 14 th , 30 th days) and combined influence have similar nature, but differ in a degree of expression and manifest by reactive and destructive changes of organelles. Associated neurons showed relative resistance to investigated influences in comparison with multi-polar neurons of ganglionic layer. Combined ionizing radiation and light cause substantial growth of number of hyper-chrome and picnotic multi-polar neurons of ganglionic layer of a retina. Synergic effect is mostly expressed on 7-th-14-th day of the experiment and results in progressing growth of the number of hyper chrome multi-polar neurons.