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Studying theEndothelialGlycocalyx in vitro:What Is Missing? Andrew B. HaymetNicole BartnikowskiE. Wood2021 год

Studying the Endothelial Glycocalyx in vitro: What Is Missing?
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: All human cells are coated by a surface layer of proteoglycans, glycosaminoglycans (GAGs) and plasma proteins, called the glycocalyx. The glycocalyx transmits shear stress to the cytoskeleton of endothelial cells, maintains a selective permeability barrier, and modulates adhesion of blood leukocytes and platelets. Major components of the glycocalyx, including syndecans, heparan sulfate, and hyaluronan, are shed from the endothelial surface layer during conditions including ischaemia and hypoxia, sepsis, atherosclerosis, diabetes, renal disease, and some viral infections. Studying mechanisms of glycocalyx damage in vivo can be challenging due to the complexity of immuno-inflammatory responses which are inextricably involved. Previously, both static as well as perfused in vitro models have studied the glycocalyx, and have reported either imaging data, assessment of barrier function, or interactions of blood components with the endothelial monolayer. To date, no model has simultaneously incorporated all these features at once, however such a model would arguably enhance the study of vasculopathic processes. This review compiles a series of current in vitro models described in the literature that have targeted the glycocalyx layer, their limitations, and potential opportunities for further developments in this field.
Год издания: 2021
Авторы: Andrew B. Haymet, Nicole Bartnikowski, E. Wood, Michael P. Vallely, Angela McBride, Sophie Yacoub, Scott B. Biering, Eva Harris, Jacky Y. Suen, John F. Fraser
Издательство: Frontiers Media
Источник: Frontiers in Cardiovascular Medicine
Ключевые слова: Trauma, Hemostasis, Coagulopathy, Resuscitation, Hemoglobin structure and function, Blood transfusion and management
Другие ссылки: Frontiers in Cardiovascular Medicine (PDF)
Frontiers in Cardiovascular Medicine (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
QUT ePrints (Queensland University of Technology) (HTML)
OPAL (Open@LaTrobe) (La Trobe University) (PDF)
OPAL (Open@LaTrobe) (La Trobe University) (HTML)
Oxford University Research Archive (ORA) (University of Oxford) (PDF)
Oxford University Research Archive (ORA) (University of Oxford) (HTML)
Griffith Research Online (Griffith University, Queensland, Australia) (PDF)
Griffith Research Online (Griffith University, Queensland, Australia) (HTML)
PubMed Central (HTML)
Sussex Research Online (University of Sussex) (HTML)
PubMed (HTML)