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Soft, skin-interfacedsweat stickers forcystic fibrosisdiagnosis andmanagement Tyler R. RayMaja IvanovicP. Curtis2021 год

Soft, skin-interfaced sweat stickers for cystic fibrosis diagnosis and management
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: The concentration of chloride in sweat remains the most robust biomarker for confirmatory diagnosis of cystic fibrosis (CF), a common life-shortening genetic disorder. Early diagnosis via quantitative assessment of sweat chloride allows prompt initiation of care and is critically important to extend life expectancy and improve quality of life. The collection and analysis of sweat using conventional wrist-strapped devices and iontophoresis can be cumbersome, particularly for infants with fragile skin, who often have insufficient sweat production. Here, we introduce a soft, epidermal microfluidic device ("sweat sticker") designed for the simple and rapid collection and analysis of sweat. Intimate, conformal coupling with the skin supports nearly perfect efficiency in sweat collection without leakage. Real-time image analysis of chloride reagents allows for quantitative assessment of chloride concentrations using a smartphone camera, without requiring extraction of sweat or external analysis. Clinical validation studies involving patients with CF and healthy subjects, across a spectrum of age groups, support clinical equivalence compared to existing device platforms in terms of accuracy and demonstrate meaningful reductions in rates of leakage. The wearable microfluidic technologies and smartphone-based analytics reported here establish the foundation for diagnosis of CF outside of clinical settings.
Год издания: 2021
Авторы: Tyler R. Ray, Maja Ivanovic, P. Curtis, Daniel Franklin, Kerem Guventurk, William J. Jeang, Joseph Chafetz, Hannah Gaertner, Grace Young, Steve Rebollo, Jeffrey B. Model, Stephen P. Lee, John Ciraldo, Jonathan T. Reeder, Aurélie Hourlier‐Fargette, Amay J. Bandodkar, Jungil Choi, Alexander J. Aranyosi, Roozbeh Ghaffari, Susanna A. McColley, Shannon Haymond, John A. Rogers
Издательство: American Association for the Advancement of Science
Источник: Science Translational Medicine
Ключевые слова: Cystic Fibrosis Research Advances, Advanced Sensor and Energy Harvesting Materials, Biosensors and Analytical Detection
Другие ссылки: Science Translational Medicine (HTML)
HAL (Le Centre pour la Communication Scientifique Directe) (PDF)
HAL (Le Centre pour la Communication Scientifique Directe) (HTML)
PubMed Central (HTML)
HAL (Le Centre pour la Communication Scientifique Directe) (HTML)
HAL (Le Centre pour la Communication Scientifique Directe) (HTML)
PubMed (HTML)