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Current Management ofPatients with RPE65Mutation-AssociatedInherited RetinalDegenerations inEurope Birgit LorenzJoana TavaresL. Ingeborgh van den Born2021 год

Current Management of Patients with <b><i>RPE65</i></b> Mutation-Associated Inherited Retinal Degenerations in Europe: Results of a Multinational Survey by the European Vision Institute Clinical Research Network
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Аннотация: <b><i>Purpose:</i></b> The first ocular gene augmentation therapy, voretigene neparvovec (VN) (Luxturna®), has been approved for clinical use in an increasing number of countries (FDA USA 2017, EMA Europe 2018, MoHAP United Arab Emirates 2019, SFDA Saudi Arabia 2019, Swiss Medic Switzerland 2020, TGA Australia 2020, BFR Brazil 2020). Among the EVICR.net clinical centers, we conducted the first multinational survey to understand distribution, diagnostic work-up, and management of inherited retinal degeneration (IRD) cases in Europe with a special focus on <i>RPE65</i> mutation-associated IRDs. <b><i>Methods:</i></b> An electronic survey questionnaire including 35 questions specifically addressing <i>RPE65</i> mutation-associated IRDs was developed and sent to the 101 EVICR.net clinical centers. <b><i>Results:</i></b> The overall response rate was 49%. Forty-two centers see IRD patients, and 22/42 follow patients with confirmed biallelic <i>RPE65</i> mutations. Fifteen of the 22 centers (68%) and 3/22 (14%) follow 1–5 and 6–10 patients with homozygous <i>RPE65</i> mutations, respectively. Additionally, 15/22 (68%) and 3/22 (14%) follow 1–5 and &#x3e;20 patients with compound heterozygous <i>RPE65</i> mutations, respectively. Fifty-nine percent of mutations were ACMG Class 4 and 5 (at least 1 allele), 82.8% reported previously and 17.2% novel. Referral diagnoses (the mean per center) were Leber congenital amaurosis (38.2%), early-onset severe retinal degeneration (16.8%), rod-cone-dystrophy/retinitis pigmentosa (RP) (28.1%), and unclassified visual impairment (17.0%). Twenty-five percent of the centers changed the referral diagnosis in &#x3e;47.5% of cases; 32% follow a specific referral process for <i>RPE65</i> mutation-associated IRD patients. Annual follow-up visits are done in 55% of the centers and biannual visits in 23%. In 32%, other centers also follow the patients. Kinetic perimetry is done in 82%, static perimetry in 45%, and microperimetry in 18% of the centers. Full-field light stimulus threshold testing with blue and red stimuli to quantify the rod and cone function is used in 6/22 centers (27%). A mobility course is available in one center (5%). <b><i>Conclusion:</i></b> This first multinational survey on management of patients with <i>RPE65</i> mutation-associated IRDs in Europe shows that about half of the responding EVICR.net centers have such patients under care. There is heterogeneity in diagnoses and management practices. At the start of clinical practice experience with VN, these data provide a useful baseline and highlight the need for consensus/guidelines to inform standard of care in this new era of gene therapy.
Год издания: 2021
Авторы: Birgit Lorenz, Joana Tavares, L. Ingeborgh van den Born, João Pedro Marques, Hendrik P. N. Scholl
Издательство: Karger Publishers
Источник: Ophthalmic Research
Ключевые слова: Retinal Development and Disorders, Retinal Diseases and Treatments, Retinal and Macular Surgery
Другие ссылки: Ophthalmic Research (PDF)
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Informationszentrum Lebenswissenschaften (ZB MED) (PDF)
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