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G-quadruplexes: apromising target forcancer therapy Nils KosiolStefan JuranekPeter Brossart2021 год

G-quadruplexes: a promising target for cancer therapy
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: DNA and RNA can fold into a variety of alternative conformations. In recent years, a particular nucleic acid structure was discussed to play a role in malignant transformation and cancer development. This structure is called a G-quadruplex (G4). G4 structure formation can drive genome instability by creating mutations, deletions and stimulating recombination events. The importance of G4 structures in the characterization of malignant cells was currently demonstrated in breast cancer samples. In this analysis a correlation between G4 structure formation and an increased intratumor heterogeneity was identified. This suggests that G4 structures might allow breast cancer stratification and supports the identification of new personalized treatment options. Because of the stability of G4 structures and their presence within most human oncogenic promoters and at telomeres, G4 structures are currently tested as a therapeutic target to downregulate transcription or to block telomere elongation in cancer cells. To date, different chemical molecules (G4 ligands) have been developed that aim to target G4 structures. In this review we discuss and compare G4 function and relevance for therapeutic approaches and their impact on cancer development for three cancer entities, which differ significantly in their amount and type of mutations: pancreatic cancer, leukemia and malignant melanoma. G4 structures might present a promising new strategy to individually target tumor cells and could support personalized treatment approaches in the future.
Год издания: 2021
Авторы: Nils Kosiol, Stefan Juranek, Peter Brossart, Annkristin Heine, Katrin Paeschke
Издательство: BioMed Central
Источник: Molecular Cancer
Ключевые слова: DNA and Nucleic Acid Chemistry, Advanced biosensing and bioanalysis techniques, RNA Interference and Gene Delivery
Другие ссылки: Molecular Cancer (PDF)
Molecular Cancer (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
PubMed Central (HTML)
PubMed (HTML)