Adaptive immunity to SARS-CoV-2 in cancer patients: The CAPTURE studypreprint
Аннотация: SUMMARY There is a pressing need to characterise the nature, extent and duration of immune response to SARS-CoV-2 in cancer patients and inform risk-reduction strategies and preserve cancer outcomes. CAPTURE is a prospective, longitudinal cohort study of cancer patients and healthcare workers (HCWs) integrating longitudinal immune profiling and clinical annotation. We evaluated 529 blood samples and 1051 oronasopharyngeal swabs from 144 cancer patients and 73 HCWs and correlated with >200 clinical variables. In patients with solid cancers and HCWs, S1-reactive and neutralising antibodies to SARS-CoV-2 were detectable five months post-infection. SARS-CoV-2-specific T-cell responses were detected, and CD4 + T-cell responses correlated with S1 antibody levels. Patients with haematological malignancies had impaired but partially compensated immune responses. Overall, cancer stage, disease status, and therapies did not correlate with immune responses. These findings have implications for understanding individual risks and potential effectiveness of SARS-CoV-2 vaccination in the cancer population.
Год издания: 2020
Авторы: Annika Fendler, Lewis Au, Laura Amanda Boos, Fiona Byrne, Scott Shepherd, Benjamin Shum, Camille L. Gérard, Sophia Ward, Wenyi Xie, Maddalena Cerrone, Georgina H. Cornish, Martin Pulé, Leila Mekkaoui, Kevin W. Ng, Richard Stone, Camila Gomes, Helen R. Flynn, Ana Agua‐Doce, P. Hobson, Simon Caidan, M. René Howell, Robert Goldstone, Mike Gavrielides, Emma Nye, Ambrosius P. Snijders, James I. MacRae, Jérôme Nicod, Adrian Hayday, Firza Alexander Gronthoud, Christina Messiou, David Cunningham, Ian Chau, Naureen Starling, Nicholas C. Turner, Jennifer Rusby, Liam Welsh, Nicholas van As, Robin L. Jones, Joanne Droney, Susana Banerjee, Kate Tatham, Shaman Jhanji, Mary O’Brien, Olivia Curtis, Kevin J. Harrington, Shreerang Bhide, Tim Slattery, Yasir Khan, Zayd Tippu, Isla Leslie, Spyridon Gennatas, Alicia Okines, Alison Reid, Kate Young, Andrew J.S. Furness, Lisa Pickering, Sonia Ghandi, Steve Gamblin, Charles Swanton, Emma Nicholson, Sacheen Kumar, Nadia Yousaf, Katalin A. Wilkinson, Anthony J. Swerdlow, Ruth Harvey, George Kassiotis, Robert J. Wilkinson, James Larkin, Samra Turajlic
Издательство: Cold Spring Harbor Laboratory
Источник: medRxiv (Cold Spring Harbor Laboratory)
Ключевые слова: SARS-CoV-2 and COVID-19 Research, COVID-19 and healthcare impacts, COVID-19 Clinical Research Studies
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