Аннотация:This research computed the combined effects of self-esteem, self-efficacy, and locus of control as predictors of academic performance of students in different universities of Karachi by using the Regression model. Previous researches were correlational studies in nature and reported the moderate positive correlations between the variables self-esteem, self-efficacy, and locus of control and academic performance. A questionnaire with 40 items related to self-esteem, self-efficacy,locus of control, and academic performance was designed. The data was collected from the public and private universities of Karachi. Descriptive Statistics, t-test, Correlation, and Regression were calculated through SPSS. The regression model showed that self-esteem, self-efficacy, Locus of Control significantly predicted the academic performance of the graduate students. In Structural Equation Modeling self-efficacy contributed more to the academic performance of students. Thisresearch recommends more future researches for in-depth analysis of latent variables as the idea has not researched its maturity in the context of higher education in Pakistan.