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Covid-19 and bloodgroups: ABO antibodylevels may alsomatter Marie DeleersAdrien BreimanValéry Daubie2020 год

Covid-19 and blood groups: ABO antibody levels may also matter
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Аннотация: BackgroundSusceptibility to Covid-19 has been found to be associated with the ABO blood group, with O type individuals being at a lower risk. However, the underlying mechanism has not been elucidated. Here, we aimed to test the hypothesis that Covid-19 patients might have lower levels of ABO antibodies than non-infected individuals as they could offer some degree of protection.MethodsAfter showing that the viral spike protein harbors the ABO glycan epitopes when produced by cells expressing the relevant glycosyltransferases, like upper respiratory tract epithelial cells, we enrolled 290 patients with Covid-19 and 276 asymptomatic controls to compare their levels of natural ABO blood group antibodies.ResultsWe found significantly lower IgM anti-A + anti-B agglutination scores in blood group O patients (76.93 vs 88.29, P-value = 0.034) and lower levels of anti-B (24.93 vs 30.40, P-value = 0.028) and anti-A antibodies (28.56 vs 36.50, P-value = 0.048) in blood group A and blood group B patients, respectively, compared to controls.ConclusionIn this study, we showed that ABO antibody levels are significantly lower in Covid-19 patients compared to controls. These findings could indicate that patients with low levels of ABO antibodies are at higher risk of being infected.
Год издания: 2020
Авторы: Marie Deleers, Adrien Breiman, Valéry Daubie, Carine Maggetto, Isabelle Barreau, T. Besse, Béatrice Clémenceau, Nathalie Ruvoën‐Clouet, Jean‐François Fils, Evelyne Maillart, V. Doyen, Bhavna Mahadeb, Jacques Jani, P. Van der Linden, Mieke Cannie, Nabil Hayef, Francis Corazza, Jacques Le Pendu, Hanane El Kenz
Издательство: Elsevier BV
Источник: International Journal of Infectious Diseases
Ключевые слова: Blood groups and transfusion, Diabetes and associated disorders, Blood disorders and treatments
Другие ссылки: International Journal of Infectious Diseases (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (HTML)
VUBIR (Vrije Universiteit Brussel) (HTML)
PubMed Central (HTML)
PubMed (HTML)