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Standardization of aCrude Drug Moringaoleifera Leaf fromAfrica, India andLocal (Indonesian)which Cultivated inBojonegoro Indonesia 2020 год

Standardization of a Crude Drug Moringa oleifera Leaf from Africa, India and Local (Indonesian) which Cultivated in Bojonegoro Indonesia
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Аннотация: Purpose:The research was to determine specific parameters (macroscopy and microscopy) and non-specific parameters (loss on drying, total ash content, acid insoluble ash content, water-soluble extractive matter, ethanol-soluble extractive matter), heavy metal contaminant (Pb, Hg, As, Cu) and microbial contaminant (Total Plate Count and Total Yeast Mold).Research also determined a total flavonoid of M. oleifera leaf.Methodology: The method carried out according to the procedure stated in the Materia Medika Indonesia 5 th edition.Result test compared to the standard stated in Indonesian Herbal Pharmacopoeia 2 nd edition.Methods to detection Contaminants were referred to WHO guidelines for assessing the quality of herbal medicines.The determination of total flavonoid was performed by spectroscopic method.Results: Crude drug of M. oleifera leaf meet the specific parameters (macroscopy and microscopy).Nonspecific parameters of Africa, India, Local M. oleifera leaf shows that loss on drying (8.06 ± 0.03; 8.89 ± 0.31; 7.56 ± 0.17) %, total ash content (8.64 ± 0.43; 10.64 ± 0.90; 15.31 ± 0.87) %, acid insoluble ash content (0.56 ± 0.08; 0.35 ± 0.01; 0.36 ± 0.06)%, water-soluble extractive matter (21.38 ± 1.39; 30.12 ± 2.06; 12.68 ± 1.12) %, ethanol-soluble extractive matter (39.37 ± 1.51; 27.74 ± 2.44; 27.09 ± 1.43)%, contaminant test including heavy metal contaminant shows that Pb, Cd, As and Hg were not to be detected.Microbial contaminant (Total Plate Count and Total Yeast Mold) under limits of WHO standart.Total flavonoid content of Africa, India, Local M. oleifera leaf were 8.12 ± 0.52 mg/ 100 mg QE; 10.69 ± 0.15 mg/ 100 mg QE dan 13.08 ± 0.08 mg/ 100 mg QE respectively.Conclusion: Moringa Leaves meet specific parameters (macroscopy and microscopy test).Non-specific parameter tests of Africa, India, Local Moringa Leaf shows that loss on drying, acid insoluble ash content, water-soluble extractive matter, ethanol-soluble extractive matter, contaminant test including heavy metal contaminant shows that (Pb, Cd, As and Hg) and microbial contaminant (Total Plate Count and Total Yeast Mold) meet the standard required, only total ash content did not meet the standard.Total Flavonoid content shows that the extract of M. oleifera from local (Indonesia) variety is higher than others.
Год издания: 2020
Источник: International Journal of Pharmaceutical Research
Ключевые слова: Moringa oleifera research and applications, Heavy Metals in Plants, Ethnobotanical and Medicinal Plants Studies
Другие ссылки: International Journal of Pharmaceutical Research (HTML)
Ubaya Repository (University of Surabaya) (HTML)
Ubaya Repository (University of Surabaya) (PDF)
Ubaya Repository (University of Surabaya) (HTML)
Ubaya Repository (University of Surabaya) (PDF)
Ubaya Repository (University of Surabaya) (HTML)