Аннотация:The current study was undertaken at Goat Unit of Krishi Vigyan Kendra, Durg located within the campus of College of Veterinary Science and Animal Husbandry, Anjora, Durg.Blood samples were collected from 20 adult female goats every month during summer (n=80), rainy (n=80) and winter (n=80) season to investigate the blood biochemical parameters in Osmanabadi goat.The results obtained during the investigation revealed the significant seasonal variation (P< 0.01) in all the biochemical parameters studied, i.e. serum glucose, total protein, albumin, globulin, Albumin: Globulin ratio and blood urea nitrogen (BUN).The mean total serum protein for summer was significantly higher (P< 0.01) than rainy and winter season.A similar trend was recorded in case of serum globulin and BUN values, but the reversed trend was observed in the mean values of serum albumin, A:G ratio and serum glucose.Thus, the observations of the study could able to establish the seasonal variation in biochemical parameters and could serve as reference values for Osmanabadi goat reared under the agro-climatic conditions of Chhattisgarh plains lies in the central zone of India. HIGHLIGHTSm Biochemical profiling of Osmanabadi goats reared under different management systems in Chhattisgarh plains.m Significant seasonal variations were observed in all the biochemical parameters studied.