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Social cognitionimpairment in geneticfrontotemporaldementia within theGENFI cohort Lucy L. RussellCaroline GreavesMartina Bocchetta2020 год

Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort
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Аннотация: A key symptom of frontotemporal dementia (FTD) is difficulty interacting socially with others. Social cognition problems in FTD include impaired emotion processing and theory of mind difficulties, and whilst these have been studied extensively in sporadic FTD, few studies have investigated them in familial FTD. Facial Emotion Recognition (FER) and Faux Pas (FP) recognition tests were used to study social cognition within the Genetic Frontotemporal Dementia Initiative (GENFI), a large familial FTD cohort of C9orf72, GRN, and MAPT mutation carriers. 627 participants undertook at least one of the tasks, and were separated into mutation-negative healthy controls, presymptomatic mutation carriers (split into early and late groups) and symptomatic mutation carriers. Groups were compared using a linear regression model with bootstrapping, adjusting for age, sex, education, and for the FP recognition test, language. Neural correlates of social cognition deficits were explored using a voxel-based morphometry (VBM) study. All three of the symptomatic genetic groups were impaired on both tasks with no significant difference between them. However, prior to onset, only the late presymptomatic C9orf72 mutation carriers on the FER test were impaired compared to the control group, with a subanalysis showing differences particularly in fear and sadness. The VBM analysis revealed that impaired social cognition was mainly associated with a left hemisphere predominant network of regions involving particularly the striatum, orbitofrontal cortex and insula, and to a lesser extent the inferomedial temporal lobe and other areas of the frontal lobe. In conclusion, theory of mind and emotion processing abilities are impaired in familial FTD, with early changes occurring prior to symptom onset in C9orf72 presymptomatic mutation carriers. Future work should investigate how performance changes over time, in order to gain a clearer insight into social cognitive impairment over the course of the disease.
Год издания: 2020
Авторы: Lucy L. Russell, Caroline Greaves, Martina Bocchetta, Jennifer Nicholas, Rhian S. Convery, Katrina Moore, David M. Cash, John C. van Swieten, Lize C. Jiskoot, Fermín Moreno, Raquel Sánchez‐Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Emanuela Rotondo, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonça, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Christopher Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Jason D. Warren, Jonathan D. Rohrer, Martin N. Rossor, Nick C. Fox, Ione Woollacott, Rachelle Shafei, Carolin Heller, Rita Guerreiro, José Brás, David L. Thomas, Simon Mead, Lieke Meeter, Jessica Panman, Janne M. Papma, Jackie M. Poos, Rick van Minkelen, Yolanda Pijnenburg, Myriam Barandiarán, Begoña Indakoetxea, Alazne Gabilondo, Mikel Tainta, María de Arriba, Ana Gorostidi, Miren Zulaica, Jorge Villanúa, Zigor Díaz, Sergi Borrego‐Écija, Jaume Olives, Albert Lladó, Mircea Balasa, Anna Antonell, Núria Bargalló, Enrico Premi, Maura Cosseddu MPsych, Stefano Gazzina, Alessandro Padovani, Roberto Gasparotti, Silvana Archetti, Sandra E. Black, Sara Mitchell, Ekaterina Rogaeva, Morris Freedman, Ron Keren, Daid Tang-Wai, Linn Öijerstedt, Christin Andersson, Vesna Jelić, Håkan Thonberg, Andrea Arighi, Chiara Fenoglio, Elio Scarpini, Giorgio Fumagalli, Thomas Cope, Carolyn Timberlake, Timothy Rittman, Christen Shoesmith, Robert Bartha, Rosa Rademakers, Carlo Wilke, Hans-Otto Karnarth, Benjamin Bender, Rose Bruffaerts, Philip Van Damme, Mathieu Vandenbulcke, Catarina B. Ferreira, Gabriel Miltenberger, Carolina Maruta MPsych, Ana Verdelho, Sónia Afonso, Ricardo Taipa, Paola Caroppo, Giuseppe Di Fede, Giorgio Giaccone, Cristina Muscio, Sara Prioni, Veronica Redaelli, Giacomina Rossi, Pietro Tiraboschi, Diana Duro, Maria Rosário Almeida, Miguel Castelo‐Branco, Maria João Leitão, Miguel Tábuas‐Pereira, Beatriz Santiago, Serge Gauthier, Pedro Rosa‐Neto, Michele Veldsman, Paul Thompson, Tobias Langheinrich, Catharina Prix, Tobias Hoegen, Elisabeth Wlasich, Sandra Loosli, Sonja Schönecker, Elisa Semler, Sarah Anderl‐Straub
Издательство: Elsevier BV
Источник: Cortex
Ключевые слова: Psychosomatic Disorders and Their Treatments, Mental Health and Psychiatry, Dementia and Cognitive Impairment Research
Другие ссылки: Cortex (HTML)
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