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Patient-ReportedOutcomes ofArsenic-Related SkinLesions in China Yajia LiDanrong JingYi Xiao2020 год

Patient-Reported Outcomes of Arsenic-Related Skin Lesions in China
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Аннотация: Previous studies confirmed that chronic arsenic exposure could lead to pigmentary changes and hyperkeratosis. However, skin health-related quality of life (HRQoL) among people under lifetime arsenic exposure remains underappreciated. Our study is aimed at investigating several patient-reported outcomes in a population under chronic arsenic exposure. Patients and Methods. A cross-sectional study was conducted in communities in Shimen, China. Dermatologists performed skin examinations for participants. Patient-reported outcomes (PROs) included HRQoL, itch, sleep quality, and symptoms of anxiety and depression. The Dermatology Life Quality Index (DLQI) was used to measure skin HRQoL. The numerical rating scale (NRS) was used to measure the intensity of itching. Sleep disturbance was measured by Pittsburgh Sleep Quality Index (PSQI). Anxiety and depression were measured by two-item Generalized Anxiety Disorder (GAD-2) and Patient Health Questionnaire (PHQ-2), respectively.A total of 464 participants suffering from arsenic-related skin lesions finished the assessment of DLQI. Pigmentary changes and arsenical keratosis were not associated with the patient-reported outcomes except PHQ-2. Hair arsenic exceeding 1 μg/g was associated with higher itch NRS and DLQI (P < 0.05). Itch NRS (adjusted β = 0.80, 95% CI: 0.70-0.90, P < 0.01) and hair arsenic concentration (adjusted β = 0.12, 95% CI: 0.01-0.24, P < 0.05) were independently associated with the DLQI.HRQoL, sleep quality, and mental wellbeing are impaired in residents under chronic arsenic exposure. Itching and hair arsenic are independent risk factors for impaired HRQoL.
Год издания: 2020
Авторы: Yajia Li, Danrong Jing, Yi Xiao, Xiaoyan Huang, Minxue Shen
Издательство: Hindawi Publishing Corporation
Источник: BioMed Research International
Ключевые слова: Acne and Rosacea Treatments and Effects, Skin Protection and Aging, Psoriasis: Treatment and Pathogenesis
Другие ссылки: BioMed Research International (PDF)
BioMed Research International (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
PubMed Central (HTML)
PubMed (HTML)