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Laboratory featuresof severe vs.non-severe COVID-19patients in Asianpopulations: asystematic review andmeta-analysis Sulmaz GhahramaniReza TabriziKamran Bagheri Lankarani2020 год

Laboratory features of severe vs. non-severe COVID-19 patients in Asian populations: a systematic review and meta-analysis

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Аннотация: Abstract Background More severe cases of COVID- 19 are more likely to be hospitalized and around one-fifth, needing ICU admission. Understanding the common laboratory features of COVID-19 in more severe cases versus non-severe patients could be quite useful for clinicians and might help to predict the model of disease progression. This systematic review and meta-analysis aimed to compare the laboratory test findings in severe vs. non-severe confirmed infected cases of COVID-19. Methods Electronic databases were systematically searched in PubMed, EMBASE, Scopus, Web of Science, and Google Scholar from the beginning of 2019 to 3rd of March 2020. Heterogeneity across included studies was determined using Cochrane’s Q test and the I 2 statistic. We used the fixed or random-effect models to pool the weighted mean differences (WMDs) or standardized mean differences and 95% confidence intervals (CIs). Findings Out of a total of 3009 citations, 17 articles (22 studies, 21 from China and one study from Singapore) with 3396 ranging from 12 to1099 patients were included. Our meta-analyses showed a significant decrease in lymphocyte, monocyte, and eosinophil, hemoglobin, platelet, albumin, serum sodium, lymphocyte to C-reactive protein ratio (LCR), leukocyte to C-reactive protein ratio (LeCR), leukocyte to IL-6 ratio (LeIR), and an increase in the neutrophil, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, blood urea nitrogen (BUN), creatinine (Cr), erythrocyte Sedimentation Rate (ESR), C-reactive protein (CRP), Procalcitonin (PCT), lactate dehydrogenase (LDH), fibrinogen, prothrombin time (PT), D-dimer, glucose level, and neutrophil to lymphocyte ratio (NLR) in the severe group compared with the non-severe group. No significant changes in white blood cells (WBC), Creatine Kinase (CK), troponin I, myoglobin, IL-6 and K between the two groups were observed. Interpretation This meta-analysis provides evidence for the differentiation of severe cases of COVID-19 based on laboratory test results at the time of ICU admission. Future well-methodologically designed studies from other populations are strongly recommended.
Год издания: 2020
Авторы: Sulmaz Ghahramani, Reza Tabrizi, Kamran Bagheri Lankarani, Seyyed Mohammad Amin Kashani, Shahla Rezaei, Nazanin Zeidi, Maryam Akbari, Seyed Taghi Heydari, Hamed Akbari, Peyman Nowrouzi‐Sohrabi, Fariba Ahmadizar
Издательство: BioMed Central
Источник: European journal of medical research
Ключевые слова: COVID-19 Clinical Research Studies, Long-Term Effects of COVID-19, COVID-19 and healthcare impacts
Другие ссылки: European journal of medical research (PDF)
European journal of medical research (HTML)
PubMed Central (HTML)
www.researchsquare.com (PDF)
doi.org (HTML)
PubMed (HTML)