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Therapeuticapplications ofadipose cell-freederivatives: a review Yuan CaiJianyi LiChangsha Jia2020 год

Therapeutic applications of adipose cell-free derivatives: a review

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Аннотация: Abstract Background Adipose-derived stem cells (ADSCs) have become one of the most utilized adult stem cells due to their abundance and accessibility. Recent studies have shown that paracrine cytokines, exosomes, and other active substances are the main factors through which ADSCs exert their biological effects. Main body Adipose cell-free derivatives have been recently gaining attention as potential therapeutic agents for various human diseases. These derivatives include ADSC-conditioned medium (ADSC-CM), ADSC exosomes (ADSC-Exo), and cell-free adipose tissue extracts (ATEs), all of which can be conveniently carried, stored, and transported. Currently, research on ADSC-conditioned medium (ADSC-CM) and ADSC exosomes (ADSC-Exo) is surging. Moreover, cell-free adipose tissue extracts (ATEs), obtained by purely physical methods, have emerged as the focus of research in recent years. Conclusion Adipose cell-free derivatives delivery can promote cell proliferation, migration, and angiogenesis, suppress cell apoptosis, and inflammation, as well as reduce oxidative stress and immune regulation. Thus, adipose cell-free derivatives have a broad therapeutic potential in many areas, as they possess anti-skin aging properties, promote wound healing, reduce scar formation, and provide myocardial protection and neuroprotection. This article summarizes these effects and reviews research progress in the use of adipose cell-free derivatives.
Год издания: 2020
Авторы: Yuan Cai, Jianyi Li, Changsha Jia, Yunfan He, Chengliang Deng
Издательство: BioMed Central
Источник: Stem Cell Research & Therapy
Ключевые слова: Mesenchymal stem cell research, Adipose Tissue and Metabolism, Autophagy in Disease and Therapy
Другие ссылки: Stem Cell Research & Therapy (PDF)
Stem Cell Research & Therapy (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
PubMed Central (HTML)
PubMed (HTML)