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Tracking Changes inSARS-CoV-2 Spike:Evidence that D614GIncreases Infectivityof the COVID-19 Virus Bette KorberWill FischerS. Gnanakaran2020 год

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus
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Аннотация: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies revealed a recurrent pattern of G614 increase at multiple geographic levels: national, regional, and municipal. The shift occurred even in local epidemics where the original D614 form was well established prior to introduction of the G614 variant. The consistency of this pattern was highly statistically significant, suggesting that the G614 variant may have a fitness advantage. We found that the G614 variant grows to a higher titer as pseudotyped virions. In infected individuals, G614 is associated with lower RT-PCR cycle thresholds, suggestive of higher upper respiratory tract viral loads, but not with increased disease severity. These findings illuminate changes important for a mechanistic understanding of the virus and support continuing surveillance of Spike mutations to aid with development of immunological interventions.
Год издания: 2020
Авторы: Bette Korber, Will Fischer, S. Gnanakaran, Hyejin Yoon, James Theiler, W. P. Abfalterer, Nicolas Hengartner, Elena E. Giorgi, Tanmoy Bhattacharya, Brian Foley, Kathryn M. Hastie, Matthew Parker, David G. Partridge, Cariad Evans, Timothy M. Freeman, Thushan I. de Silva, Charlene McDanal, Lautaro G. Perez, Haili Tang, Alex Moon-Walker, Sean P. J. Whelan, Celia C. LaBranche, Erica O. Saphire, David C. Montefiori, Adrienne Angyal, Rebecca L. Brown, Laura Carrilero, Luke R. Green, Danielle C. Groves, Katie Johnson, Alexander J. Keeley, Benjamin B. Lindsey, Paul J. Parsons, Mohammad Raza, Sarah L. Rowland-Jones, Darren Smith, Rachel Tucker, Dennis Wang, Matthew D. Wyles
Издательство: Cell Press
Источник: Cell
Ключевые слова: SARS-CoV-2 and COVID-19 Research, SARS-CoV-2 detection and testing, COVID-19 epidemiological studies
Другие ссылки: Cell (HTML)
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (HTML)
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (HTML)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (HTML)
www.biorxiv.org (PDF)
doi.org (HTML)
PubMed (HTML)