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Respiratory ViralInfections inExacerbation ofChronic AirwayInflammatoryDiseases: NovelMechanisms andInsights From theUpper AirwayEpithelium Kai Sen TanRachel Liyu LimJing Liu2020 год

Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Respiratory virus infection is one of the major sources of exacerbation of chronic airway inflammatory diseases. These exacerbations are associated with high morbidity and even mortality worldwide. The current understanding on viral-induced exacerbations is that viral infection increases airway inflammation which aggravates disease symptoms. Recent advances in in vitro air-liquid interface 3D cultures, organoid cultures and the use of novel human and animal challenge models have evoked new understandings as to the mechanisms of viral exacerbations. In this review, we will focus on recent novel findings that elucidate how respiratory viral infections alter the epithelial barrier in the airways, the upper airway microbial environment, epigenetic modifications including miRNA modulation, and other changes in immune responses throughout the upper and lower airways. First, we reviewed the prevalence of different respiratory viral infections in causing exacerbations in chronic airway inflammatory diseases. Subsequently we also summarized how recent models have expanded our appreciation of the mechanisms of viral-induced exacerbations. Further we highlighted the importance of the virome within the airway microbiome environment and its impact on subsequent bacterial infection. This review consolidates the understanding of viral induced exacerbation in chronic airway inflammatory diseases and indicates pathways that may be targeted for more effective management of chronic inflammatory diseases.
Год издания: 2020
Авторы: Kai Sen Tan, Rachel Liyu Lim, Jing Liu, Hsiao Hui Ong, Vivian Jiayi Tan, Hui Fang Lim, Kian Fan Chung, Ian M. Adcock, Vincent Chow, De Yun Wang
Издательство: Frontiers Media
Источник: Frontiers in Cell and Developmental Biology
Ключевые слова: Respiratory viral infections research, Pediatric health and respiratory diseases, Tracheal and airway disorders
Другие ссылки: Frontiers in Cell and Developmental Biology (PDF)
Frontiers in Cell and Developmental Biology (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
PUBLISSO (German National Library of Medicine) (PDF)
PUBLISSO (German National Library of Medicine) (HTML)
Spiral (Imperial College London) (PDF)
Spiral (Imperial College London) (HTML)
Informationszentrum Lebenswissenschaften (ZB MED) (PDF)
Informationszentrum Lebenswissenschaften (ZB MED) (HTML)
PubMed Central (HTML)
PubMed (HTML)