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Impact of screeningon cervical cancerincidence: Apopulation‐basedcase–control study inthe United States Rebecca LandyPeter SasieniChristopher Mathews2019 год

Impact of screening on cervical cancer incidence: A population‐based case–control study in the United States
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Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Cervical cancer is widely preventable through screening, but little is known about the duration of protection offered by a negative screen in North America. A case–control study was conducted with records from population‐based registries in New Mexico. Cases were women diagnosed with cervical cancer in 2006–2016, obtained from the Tumor Registry. Five controls per case from the New Mexico HPV Pap Registry were matched to cases by sex, age and place of residence. Dates and results of all cervical screening and diagnostic tests since 2006 were identified from the pap registry. We estimated the odds ratio of nonlocalized (Stage II+) and localized (Stage I) cervical cancer associated with attending screening in the 3 years prior to case‐diagnosis compared to women not screened in 5 years. Of 876 cases, 527 were aged 25–64 years with ≥3 years of potential screening data. Only 38% of cases and 61% of controls attended screening in a 3‐year period. Women screened in the 3 years prior to diagnosis had 83% lower risk of nonlocalized cancer (odds ratio [OR] = 0.17, 95% CI: 0.12–0.24) and 48% lower odds of localized cancer (OR = 0.52, 95% CI: 0.38–0.72), compared to women not screened in the 5 years prior to diagnosis. Women remained at low risk of nonlocalized cancer for 3.5–5 years after a negative screen compared to women with no negative screens in the 5 years prior to diagnosis. Routine cervical screening is effective at preventing localized and nonlocalized cervical cancers; 3 yearly screening prevents 83% of nonlocalized cancers, with no additional benefit of more frequent screening. Increasing screening coverage remains essential to further reduce cervical cancer incidence.
Год издания: 2019
Авторы: Rebecca Landy, Peter Sasieni, Christopher Mathews, Charles L. Wiggins, Michael Robertson, Yolanda J. McDonald, Daniel W. Goldberg, Isabel C. Scarinci, Jack Cuzick, Cosette M. Wheeler
Издательство: Wiley
Источник: International Journal of Cancer
Ключевые слова: Cervical Cancer and HPV Research, Global Cancer Incidence and Screening, Endometrial and Cervical Cancer Treatments
Другие ссылки: International Journal of Cancer (PDF)
International Journal of Cancer (HTML)
PubMed Central (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
Queen Mary Research Online (Queen Mary University of London) (PDF)
Queen Mary Research Online (Queen Mary University of London) (HTML)
PubMed (HTML)