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The Role of Obesityin Renal CellCarcinoma Patients:Clinical-PathologicalImplications Gaetano AurilioFrancesco PivaMatteo Santoni2019 год

The Role of Obesity in Renal Cell Carcinoma Patients: Clinical-Pathological Implications
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Obesity is a well-known risk factor for renal cell carcinoma (RCC) development. However, the RCC–obesity link has not been fully addressed when considering a comprehensive scenario starting from pathogenetic aspects through pathological issues up to the outcome of medical treatment. We therefore conducted an electronic PubMed search using keywords “obesity”, “body mass index”, “overweight”, “renal cell carcinoma/kidney cancer”, “medical treatment”, “targeted therapy”, and “immunotherapy/immune checkpoint inhibitors”. The selected data supported a crosstalk between adipose tissue (adipocytes and other white adipose tissue cells) and cancer cells inducing several signaling pathways that finally stimulated angiogenesis, survival, and cellular proliferation. Accurate sampling of renal sinus fat correlated with a prognostic value. Retrospective clinical evidence in metastatic RCC patients with higher body mass index (BMI) and treated with targeted therapies and/or immune checkpoint inhibitors showed advantageous survival outcomes. Therefore, obesity may influence the course of RCC patients, although the interplay between obesity/BMI and RCC warrants a large prospective confirmation. We are therefore still far from determining a clear role of obesity as a prognostic/predictive factor in metastatic RCC patients undergoing targeted therapy and immunotherapy.
Год издания: 2019
Авторы: Gaetano Aurilio, Francesco Piva, Matteo Santoni, Alessia Cimadamore, Giulia Sorgentoni, Antonio López-Beltrán, Liang Cheng, Nicola Battelli, Franco Nolè, Rodolfo Montironi
Издательство: Multidisciplinary Digital Publishing Institute
Источник: International Journal of Molecular Sciences
Ключевые слова: Renal cell carcinoma treatment, Multiple and Secondary Primary Cancers, Renal and related cancers
Другие ссылки: International Journal of Molecular Sciences (PDF)
International Journal of Molecular Sciences (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
Purdue University Indianapolis (Indiana University) (PDF)
Purdue University Indianapolis (Indiana University) (HTML)
PubMed Central (HTML)
PubMed (HTML)