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P2-354: MEDIALTEMPORAL LOBECORRELATES OFANOSAGNOSIA INPRODROMAL AD Laura E.M. WisseTrevor GlennSandhitsu R. Das2019 год

P2-354: MEDIAL TEMPORAL LOBE CORRELATES OF ANOSAGNOSIA IN PRODROMAL AD
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Аннотация: A lack of self-awareness of one's cognitive decline, anosagnosia, is commonly observed in prodromal Alzheimer's disease (AD). A recent review indicated that the medial temporal lobe (MTL) is implicated in anosagnosia (Chavoix and Insausti, Neurosci Biobehav Rev 2017), and especially the hippocampus, parahippocampal cortex (PHC) and perirhinal cortex (PRC). However, limited research has been done in this area. We investigated MTL subregional correlates of anosagnosia in prodromal AD using a specialized pipeline for MTL segmentation. A specialized method for MTL morphometry was used to segment T1- MRI scans of 230 β-amyloid positive Mild Cognitive Impairment (MCI) participants (Table 1) from ADNI-GO/2 to obtain anterior/posterior hippocampus, entorhinal cortex (ERC), Brodmann areas (BA) 35 and 36 (subdivitions of the PRC) and PHC. Annualized atrophy rates were estimated with an unbiased deformation-based morphometry method using follow-up MRI scans within 2.1±0.2 years. Logical memory delayed recall and total score of self and proxy assessments of cognitive performance using the Everyday Cognition Questionnaire were obtained. Anosagnosia was operationalized in two ways: 1) the difference between the self and proxy assessments and 2) the difference between logical memory and self-assessment, converted to a similar scale. For both measures a lower score represents less awareness. All MTL subregions are significantly associated with logical memory, cross-sectionally and longitudinally, and several MTL regions are associated with proxy assessments, but less so with self-assessments of cognitive performance (Table 2 and 3). Cross-sectionally, both anosagnosia measures show an association with BA35, where less awareness (lower score) is associated with thinner BA35 (Figures 1-2). For the longitudinal analyses, both anosagnosia measures are associated with a more widespread MTL atrophy pattern.
Год издания: 2019
Авторы: Laura E.M. Wisse, Trevor Glenn, Sandhitsu R. Das, de Flores Robin, Long Xie, Paul A. Yushkevich, David A. Wolk
Издательство: Wiley
Источник: Alzheimer s & Dementia
Ключевые слова: Dementia and Cognitive Impairment Research, Neurological Disease Mechanisms and Treatments, Neurological Disorders and Treatments