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Impaired brainendocannabinoid tonein the activity‐basedmodel of anorexianervosa Roberto ColluMaría SchermaFabiana Piscitelli2019 год

Impaired brain endocannabinoid tone in the activity‐based model of anorexia nervosa
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: Abstract Objective Despite the growing knowledge on the functional relationship between an altered endocannabinoid (eCB) system and development of anorexia nervosa (AN), to date no studies have investigated the central eCB tone in the activity‐based anorexia (ABA) model that reproduces key aspects of human AN. Method We measured levels of two major eCBs, anandamide (AEA) and 2‐arachidonoylglycerol (2‐AG), those of two eCB‐related lipids, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), and the cannabinoid type‐1 receptor (CB1R) density in the brain of female ABA rats, focusing on areas involved in homeostatic and rewarding‐related regulation of feeding behavior (i.e., prefrontal cortex, nucleus accumbens, caudato putamen, amygdala, hippocampus and hypothalamus). Analysis was carried out also at the end of recovery from the ABA condition. Results At the end of the ABA induction phase, 2‐AG was significantly decreased in ABA rats in different brain areas but not in the caudato putamen. No changes were detected in AEA levels in any region, whereas the levels of OEA and PEA were decreased exclusively in the hippocampus and hypothalamus. Furthermore, CB1R density was decreased in the dentate gyrus of hippocampus and in the lateral hypothalamus. After recovery, both 2‐AG levels and CB1R density were partially normalized in some areas. In contrast, AEA levels became markedly reduced in all the analyzed areas. Discussion These data demonstrate an altered brain eCB tone in ABA rats, further supporting the involvement of an impaired eCB system in AN pathophysiology that may contribute to the maintenance of some symptomatic aspects of the disease.
Год издания: 2019
Авторы: Roberto Collu, María Scherma, Fabiana Piscitelli, Elisa Giunti, Valentina Satta, Paola Castelli, Roberta Verde, Walter Fratta, Tiziana Bisogno, Paola Fadda
Издательство: Wiley
Источник: International Journal of Eating Disorders
Ключевые слова: Cannabis and Cannabinoid Research, Neuroscience of respiration and sleep, Sleep and Wakefulness Research
Другие ссылки: International Journal of Eating Disorders (HTML)
PubMed (HTML)