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Two bifunctionalinositolpyrophosphatekinases/phosphatasescontrol plantphosphate homeostasis Jinsheng ZhuKelvin LauRobert Puschmann2019 год

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis
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Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-InsPs may regulate Pi homeostasis. Here we report that deletion of two diphosphoinositol pentakisphosphate kinases VIH1/2 impairs plant growth and leads to constitutive Pi starvation responses. Deletion of phosphate starvation response transcription factors partially rescues vih1 vih2 mutant phenotypes, placing diphosphoinositol pentakisphosphate kinases in plant Pi signal transduction cascades. VIH1/2 are bifunctional enzymes able to generate and break-down PP-InsPs. Mutations in the kinase active site lead to increased Pi levels and constitutive Pi starvation responses. ATP levels change significantly in different Pi growth conditions. ATP-Mg2+ concentrations shift the relative kinase and phosphatase activities of diphosphoinositol pentakisphosphate kinases in vitro. Pi inhibits the phosphatase activity of the enzyme. Thus, VIH1 and VIH2 relay changes in cellular ATP and Pi concentrations to changes in PP-InsP levels, allowing plants to maintain sufficient Pi levels.
Год издания: 2019
Авторы: Jinsheng Zhu, Kelvin Lau, Robert Puschmann, Robert K. Harmel, Youjun Zhang, Verena Pries, Philipp Gaugler, Larissa Broger, Amit K. Dutta, Henning J. Jessen, Gabriel Schaaf, Alisdair R. Fernie, Ludwig A. Hothorn, Dorothea Fiedler, Michael Hothorn
Издательство: eLife Sciences Publications Ltd
Источник: eLife
Ключевые слова: Plant nutrient uptake and metabolism, Phytase and its Applications, Plant Micronutrient Interactions and Effects
Другие ссылки: eLife (HTML)
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Europe PMC (PubMed Central) (PDF)
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Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover) (PDF)
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access.archive-ouverte.unige.ch (PDF)
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PubMed Central (HTML)
bioRxiv (Cold Spring Harbor Laboratory) (HTML)
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