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Peripheral NervousSystem Disease inSystemic LupusErythematosus:Results From anInternationalInception CohortStudy John G. HanlyQiuju LiLi Su2019 год

Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
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Аннотация: Objective To determine the frequency, clinical characteristics, associations, and outcomes of different types of peripheral nervous system (PNS) disease in a multiethnic/multiracial, prospective inception cohort of systemic lupus erythematosus (SLE) patients. Methods Patients were evaluated annually for 19 neuropsychiatric (NP) events including 7 types of PNS disease. SLE disease activity, organ damage, autoantibodies, and patient and physician assessment of outcome were measured. Time to event and linear regressions were used as appropriate. Results Of 1,827 SLE patients, 88.8% were female, and 48.8% were white. The mean ± SD age was 35.1 ± 13.3 years, disease duration at enrollment was 5.6 ± 4.2 months, and follow‐up was 7.6 ± 4.6 years. There were 161 PNS events in 139 (7.6%) of 1,827 patients. The predominant events were peripheral neuropathy (66 of 161 [41.0%]), mononeuropathy (44 of 161 [27.3%]), and cranial neuropathy (39 of 161 [24.2%]), and the majority were attributed to SLE. Multivariate Cox regressions suggested longer time to resolution in patients with a history of neuropathy, older age at SLE diagnosis, higher SLE Disease Activity Index 2000 scores, and for peripheral neuropathy versus other neuropathies. Neuropathy was associated with significantly lower Short Form 36 (SF‐36) physical and mental component summary scores versus no NP events. According to physician assessment, the majority of neuropathies resolved or improved over time, which was associated with improvements in SF‐36 summary scores for peripheral neuropathy and mononeuropathy. Conclusion PNS disease is an important component of total NPSLE and has a significant negative impact on health‐related quality of life. The outcome is favorable for most patients, but our findings indicate that several factors are associated with longer time to resolution.
Год издания: 2019
Авторы: John G. Hanly, Qiuju Li, Li Su, Murray B. Urowitz, Caroline Gordon, Sang‐Cheol Bae, Juanita Romero‐Díaz, Jorge Sánchez‐Guerrero, Sasha Bernatsky, Ann E. Clarke, Daniel J. Wallace, David Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Kristján Steinsson, Rosalind Ramsey‐Goldman, Asad Zoma, Susan Manzi, Ola Nived, Andreas Jönsen, Munther A. Khamashta, Graciela S. Alarcón, Elisabet Svenungsson, Ronald van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz‐Irastorza, Manuel Ramos‐Casals, S Sam Lim, Murat İnanç, Kenneth Kalunian, Søren Jacobsen, Christine A. Peschken, Diane L. Kamen, Anca Askanase, Chris Theriault, Vernon T. Farewell
Издательство: Wiley
Источник: Arthritis & Rheumatology
Ключевые слова: Systemic Lupus Erythematosus Research, Systemic Sclerosis and Related Diseases, Peripheral Neuropathies and Disorders
Другие ссылки: Arthritis & Rheumatology (HTML)
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