Аннотация:The aim of the present study is to determine if saliva can be used as a marker of osteoporosis in overiectomized dogs and for the effect of hormone replacement therapy in this model.Eighteen female dogs were divided into three groups: Sham operated, ovariectomized (OVX) and ovariectomized treated with hormone replacement therapy (HRT).Unstimulated saliva was collected to measure flow rate ml/hour, outputs of α-amylase, total protein, bicarbonate and calcium.Bone turnover was estimated by measuring serum and salivary osteocalcin.The results of the present work showed that ovariectomy (OVX) produces a significant decrease in salivary flow rate and outputs of salivary constituents studied with significant negative correlation with both salivary and serum osteocalcin.While ovariectomy with hormone replacement therapy decrease salivary and serum osteocalcin and causes a significant increase in flow of saliva and outputs of all salivary parameters that show significant negative correlation with both osteocalcins, however the flow rate and outputs of all salivary constituents, serum and salivary osteocalcin does not return to sham operated level.In Conclusion the flow rate and output of these salivary parameters are improved by HRT and that whole saliva is considered as a valuable tool for assessing human marker of bone turnover.
