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Genome‐wide analysisof adolescentpsychotic‐likeexperiences showsgenetic overlap withpsychiatric disorders Oliver PainFrank DudbridgeAlastair G. Cardno2018 год

Genome‐wide analysis of adolescent psychotic‐like experiences shows genetic overlap with psychiatric disorders
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Аннотация: This study aimed to test for overlap in genetic influences between psychotic-like experience traits shown by adolescents in the community, and clinically-recognized psychiatric disorders in adulthood, specifically schizophrenia, bipolar disorder, and major depression. The full spectra of psychotic-like experience domains, both in terms of their severity and type (positive, cognitive, and negative), were assessed using self- and parent-ratings in three European community samples aged 15-19 years (Final N incl. siblings = 6,297-10,098). A mega-genome-wide association study (mega-GWAS) for each psychotic-like experience domain was performed. Single nucleotide polymorphism (SNP)-heritability of each psychotic-like experience domain was estimated using genomic-relatedness-based restricted maximum-likelihood (GREML) and linkage disequilibrium- (LD-) score regression. Genetic overlap between specific psychotic-like experience domains and schizophrenia, bipolar disorder, and major depression was assessed using polygenic risk score (PRS) and LD-score regression. GREML returned SNP-heritability estimates of 3-9% for psychotic-like experience trait domains, with higher estimates for less skewed traits (Anhedonia, Cognitive Disorganization) than for more skewed traits (Paranoia and Hallucinations, Parent-rated Negative Symptoms). Mega-GWAS analysis identified one genome-wide significant association for Anhedonia within IDO2 but which did not replicate in an independent sample. PRS analysis revealed that the schizophrenia PRS significantly predicted all adolescent psychotic-like experience trait domains (Paranoia and Hallucinations only in non-zero scorers). The major depression PRS significantly predicted Anhedonia and Parent-rated Negative Symptoms in adolescence. Psychotic-like experiences during adolescence in the community show additive genetic effects and partly share genetic influences with clinically-recognized psychiatric disorders, specifically schizophrenia and major depression.
Год издания: 2018
Авторы: Oliver Pain, Frank Dudbridge, Alastair G. Cardno, Daniel Freeman, Yi Lu, Sebastian Lundström, Paul Lichtenstein, Angelica Ronald
Издательство: Wiley
Источник: American Journal of Medical Genetics Part B Neuropsychiatric Genetics
Ключевые слова: Genetic Associations and Epidemiology, Adolescent and Pediatric Healthcare, Bipolar Disorder and Treatment
Другие ссылки: American Journal of Medical Genetics Part B Neuropsychiatric Genetics (PDF)
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