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Severe influenzapneumonitis inchildren withinherited TLR3deficiency Hye Kyung LimSarah X.L. HuangJie Chen2019 год

Severe influenza pneumonitis in children with inherited TLR3 deficiency
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Аннотация: Autosomal recessive IRF7 and IRF9 deficiencies impair type I and III IFN immunity and underlie severe influenza pneumonitis. We report three unrelated children with influenza A virus (IAV) infection manifesting as acute respiratory distress syndrome (IAV-ARDS), heterozygous for rare TLR3 variants (P554S in two patients and P680L in the third) causing autosomal dominant (AD) TLR3 deficiency. AD TLR3 deficiency can underlie herpes simplex virus-1 (HSV-1) encephalitis (HSE) by impairing cortical neuron-intrinsic type I IFN immunity to HSV-1. TLR3-mutated leukocytes produce normal levels of IFNs in response to IAV. In contrast, TLR3-mutated fibroblasts produce lower levels of IFN-β and -λ, and display enhanced viral susceptibility, upon IAV infection. Moreover, the patients’ iPSC-derived pulmonary epithelial cells (PECs) are susceptible to IAV. Treatment with IFN-α2b or IFN-λ1 rescues this phenotype. AD TLR3 deficiency may thus underlie IAV-ARDS by impairing TLR3-dependent, type I and/or III IFN–mediated, PEC-intrinsic immunity. Its clinical penetrance is incomplete for both IAV-ARDS and HSE, consistent with their typically sporadic nature.
Год издания: 2019
Авторы: Hye Kyung Lim, Sarah X.L. Huang, Jie Chen, Gaspard Kerner, Olivier Gilliaux, Paul Bastard, Kerry Dobbs, Nicholas Hernandez, Nicolas Goudin, Mary L. Hasek, Eduardo J. Garcia Reino, Fabien G. Lafaille, Lazaro Lorenzo, Priya Luthra, Tatiana Kochetkov, Benedetta Bigio, Soraya Boucherit, Flore Rozenberg, C. Védrinne, Michael D. Keller, Yuval Itan, Adolfo García‐Sastre, M. Célard, Jordan S. Orange, Michael J. Ciancanelli, Isabelle Meyts, Qian Zhang, Laurent Abel, Luigi D. Notarangelo, Hans‐Willem Snoeck, Jean‐Laurent Casanova, Shen‐Ying Zhang
Издательство: Rockefeller University Press
Источник: The Journal of Experimental Medicine
Ключевые слова: Respiratory viral infections research, Immune Response and Inflammation, Immunodeficiency and Autoimmune Disorders
Другие ссылки: The Journal of Experimental Medicine (HTML)
Europe PMC (PubMed Central) (PDF)
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