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Characterization of alarge cluster ofHIV-1 A1 infectionsdetected in Portugaland connected toseveral WesternEuropean countries Pedro AraújoAlexandre CarvalhoMarta Pingarilho2019 год

Characterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countries
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Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: HIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 closely related database sequences. 80% of the A1 Portuguese isolates gathered in a main phylogenetic clade (MA1). Six transmission clusters were identified in MA1, encompassing isolates from Portugal, Spain, France, and United Kingdom. The most common transmission route identified was men who have sex with men. The origin of the MA1 was linked to Greece, with the first introduction to Portugal dating back to 1996 (95% HPD: 1993.6-1999.2). Individuals infected with MA1 virus revealed lower viral loads and higher CD4+ T-cell counts in comparison with those infected by subtype B. The expanding A1 clusters in Portugal are connected to other European countries and share a recent common ancestor with the Greek A1 outbreak. The recent expansion of this HIV-1 subtype might be related to a slower disease progression leading to a population level delay in its diagnostic.
Год издания: 2019
Авторы: Pedro Araújo, Alexandre Carvalho, Marta Pingarilho, DANIEL HENRIQUE DE FARIA, Raquel Pinho, José Manuel Martins Ferreira, Paula Proença, Sofia Nunes, Margarida Mouro, Eugénio Teófilo, Sofia Pinheiro, Fernando Maltêz, Maria José Manata, Isabel Germano, Joana Simões, Olga Costa, Rita Côrte‐Real, António Diniz, Margarida Serrado, Luís Caldeira, Nuno Janeiro, Guilhermina Gaião, José Melo‐Cristino, Kamal Mansinho, Teresa Baptista, Perpétua Gómes, Isabel Diogo, Rosário Serrão, C.F.S. Pinheiro, Carmo Koch, Fátima Monteiro, Anabela Susana de Sousa Gonçalves, Rui Sarmento e Castro, Helena Ramos, Joaquim Oliveira, José Saraiva da Cunha, Vanda Mota, Fernando Rodrigues, Raquel Tavares, Rita Silva, Fausto Roxo, MAURICIO MENEZES ABEN ATHAR IVO, José Poças, Bianca Branco Ascenção, Patrícia Pacheco, Micaela Caixeiro, Nuno Marques, Maria João Aleixo, Telo Faria, Elisabete Gomes da Silva, Ricardo Correia de Abreu, I Neves, Ana Abecasis, Nuno S. Osório
Издательство: Nature Portfolio
Источник: Scientific Reports
Ключевые слова: HIV Research and Treatment, HIV/AIDS drug development and treatment, Hepatitis C virus research
Другие ссылки: Scientific Reports (PDF)
Scientific Reports (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
PubMed Central (HTML)
PubMed (HTML)